POU3F2, POU class 3 homeobox 2, 5454

N. diseases: 40; N. variants: 1
Disease: Small cell carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.040 AlteredExpression disease BEFREE Forced expression of the INSM1 gene in adenocarcinoma cell lines (H358 and H1975) induced the expression of ASCL1, brain-2 (BRN2), chromogranin A, synaptophysin, and neural cell adhesion molecule 1; in contrast, knockdown of the INSM1 gene by siRNA in SCLC (H69 and H889) decreased their expression. 26482608 2015
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.040 AlteredExpression disease BEFREE Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer. 23358112 2013
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.040 Biomarker disease BEFREE These findings suggest that BRN2 is a higher level regulator than ASCL1 and ND1 and BRN2 might be involved in aggressiveness of SCLC. 23530560 2013
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.040 AlteredExpression disease BEFREE In DNA binding studies using a consensus octamer recognition site we have found that 4 of 8 MCC cell lines examined expressed brn-2 in at least trace amounts compared with 3 SCLC cell lines which all expressed brn-2 proteins at high levels. 8026890 1994