DLL4, delta like canonical Notch ligand 4, 54567

N. diseases: 219; N. variants: 15
Disease: Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes 		0.020 Biomarker disease BEFREE Using loss-of-function genetic approaches, we demonstrate that Notch1 inactivation in keratinocytes is sufficient to cancel the repressive effects of the Dll4-Notch1 loop on wound healing in diabetes, thus making Notch1 signaling an attractive locally therapeutic target for the treatment of DFUs. 30886104 2019
CUI: C0011847
Disease: Diabetes
Diabetes 		0.020 Biomarker disease BEFREE Thus, anti-Dll4 represents a therapeutic approach for compromised insulin production in diabetes. 29606343 2018