|
Leukemia, Myelocytic, Acute
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Dysregulation of the Pit/Oct/Unc (POU) domain-containing transcription factor POU4F1 is a recurring abnormality in t(8;21) AML.
|
20376082 |
2010 |
|
Leukemia, Myelocytic, Acute
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia.
|
20460523 |
2010 |
|
Leukemia, Myelocytic, Acute
|
0.320 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
|
cervical cancer
|
0.320 |
Biomarker
|
disease |
BEFREE |
These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.
|
12911730 |
2004 |
|
cervical cancer
|
0.320 |
Biomarker
|
disease |
CTD_human |
We observed that BRN3A is independent of the regulative activity of HIPK2 and undergoes positive autoregulation in cervical cancer cells.
|
21928122 |
2011 |
|
cervical cancer
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
The elevated levels of Brn-3a in the CIN3 patient samples, together with the activating effect of Brn-3a on HPV-16 and -18 oncogene expression, suggest that induction of this factor is involved in activating HPV-16 and -18 oncogene expression in the cervix, and hence in the production of cervical cancers induced by HPV.
|
9541499 |
1998 |
|
Cervical Intraepithelial Neoplasia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Importantly, women smokers with high levels of Brn-3a infected with low- or high-risk HPV-16 variants have augmented E6 levels, and were more frequently diagnosed with higher grades of cervical intraepithelial neoplasia (CIN) and cancer, as compared with non-smokers who were infected with similar variants and expressed similar levels of Brn-3a.
|
20190800 |
2010 |
|
Cervical Intraepithelial Neoplasia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Therefore, this study defines the specific interplay between the cellular transactivator Brn-3a, the environmental smoking-related substance nicotine and specific HPV variants in cervical carcinogenesis, and thus helps to explain why some women are susceptible to rapid CIN progression and cancer and others are not.
|
20190800 |
2010 |
|
Carcinoma in situ of uterine cervix
|
0.310 |
Biomarker
|
disease |
CTD_human |
The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix.
|
20190800 |
2010 |
|
Carcinoma in situ of uterine cervix
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
The elevated levels of Brn-3a in the CIN3 patient samples, together with the activating effect of Brn-3a on HPV-16 and -18 oncogene expression, suggest that induction of this factor is involved in activating HPV-16 and -18 oncogene expression in the cervix, and hence in the production of cervical cancers induced by HPV.
|
9541499 |
1998 |
|
Uterine Cervical Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells.
|
21928122 |
2011 |
|
Acute Myeloid Leukemia, M1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
|
Acute Myeloid Leukemia (AML-M2)
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
|
18206229 |
2008 |
|
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation.
|
8782654 |
1996 |
|
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Similarly, reduction of Brn-3a expression using anti-sense constructs reduces endogenous p53 expression in human neuroblastoma or cervical carcinoma cell lines growing in vitro and as tumours in nude mice whilst increasing Brn-3a levels enhances p53 expression.
|
12431761 |
2002 |
|
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Here we show that the neuronal marker BRN3A/POU4F1 is expressed abundantly at the protein level in primary EFT but not in rhabdomyosarcoma and neuroblastoma, and EFT cells exhibit high activity of the BRN3A proximal autoregulatory region.
|
20348952 |
2010 |
|
Neuroblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepitheliomas and Ewing's sarcomas but not neuroblastomas.
|
1357630 |
1992 |
|
Ocular Hypertension
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Here we review the anatomical loss of the general population of RGCs (that express Brn3a; Brn3a<sup>+</sup>RGCs) and of the intrinsically photosensitive RGCs (that express melanopsin; m<sup>+</sup>RGCs) after chronic (LP-OHT) or acute (A-OHT) ocular hypertension and after complete intraorbital optic nerve transection (ONT) or crush (ONC).
|
28491019 |
2017 |
|
Ocular Hypertension
|
0.030 |
Biomarker
|
disease |
BEFREE |
In vivo studies in Adult Dark Agouti (DA) rats with unilateral surgically-induced ocular hypertension (OHT) treated with either CoQ10/TPGS micelles or TPGS vehicle twice daily for three weeks were performed, following which retinal cell health was assessed in vivo using DARC (Detection of Apoptotic Retinal Cells) and post-mortem with Brn3a histological assessment on whole retinal mounts.
|
28549843 |
2017 |
|
Ocular Hypertension
|
0.030 |
Biomarker
|
disease |
BEFREE |
Results showed that AOH injury reduced the number of Brn3a-stained retinal ganglion cells (RGCs) and ChAT-amacrine cells; thinned the inner retinal layers and induced apoptosis.
|
30633922 |
2019 |
|
Papilloma
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a.
|
16247485 |
2006 |
|
Papilloma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells.
|
10497216 |
1999 |
|
Papilloma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The cervical cellular transcription factors Brn-3a and Brn-3b have antagonistic effects on transcription of the human papilloma virus types 16 and 18 E6 and E7 oncogenes, with Brn-3a activating expression and Brn-3b repressing it.
|
9541499 |
1998 |
|
Synovial Cyst
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cell loss at the ganglion cell layer was assessed with terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) assay and by evaluating the immunoreactivity of the Brn3a transcription factor.
|
29853770 |
2018 |
|
Synovial Cyst
|
0.030 |
Biomarker
|
disease |
BEFREE |
The death of RGCs at day 14 was significantly reduced in CAPE‑treated animals compared with the non‑treated group according to Brn3a and TUNEL staining.
|
31059064 |
2019 |