POU5F1B, POU class 5 homeobox 1B, 5462

N. diseases: 36; N. variants: 21
Disease: Prostate carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 31562322 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease BEFREE Although none remained significant after adjustment for multiple testing (q>0.05), of the 50 CpG sites meeting quality control, we identified 8 sites that were nominally associated with prostate cancer (P<sub>trend</sub><0.05), including 6 correlated (Spearman ρ: 0.20-0.52) sites in POU5F1B and 2 intergenic sites (most significant site: Chr8:128428897 in POU5F1B, P<sub>trend</sub>=0.01). 28463958 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 Biomarker disease BEFREE MYC and POU5F1B) were identified in both prostate cancer cell lines. 26934861 2016
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT Two susceptibility loci identified for prostate cancer aggressiveness. 25939597 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. 26034056 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. 24753544 2014
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT Genome-wide association scan for variants associated with early-onset prostate cancer. 24740154 2014
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease BEFREE These included correlations between an intergenic CpG site at Chr8:128393157 and the prostate cancer SNP rs16902094 (ρ = -0.54; P = 9.7 × 10(-7); q = 0.002), a PRNCR1 CpG site at Chr8:128167809 and the prostate cancer SNP rs1456315 (ρ = 0.52; P = 1.4 × 10(-6); q = 0.002), and two POU5F1B CpG sites and several prostate/colorectal cancer SNPs (for Chr8:128498051 and rs6983267, ρ = 0.46; P = 2.0 × 10(-5); q = 0.01). 25315430 2014
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease BEFREE We highlight a Stage II interaction between the major prostate cancer susceptibility locus in the subregion of 8q24 that contains POU5F1B and an intronic SNP in the transcription factor EPAS1, which has potentially important functional implications for 8q24. 21372204 2011
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 AlteredExpression disease BEFREE The over-expression of POU5F1P1 in prostatic carcinoma in addition to its genomic location and the putative function of its gene product render POU5F1P1 a good candidate to harbour functional genetic variants which modulate prostatic cancer susceptibility. 20017164 2010
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT Multiple newly identified loci associated with prostate cancer susceptibility. 18264097 2008
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT Multiple loci identified in a genome-wide association study of prostate cancer. 18264096 2008
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.150 GeneticVariation disease GWASCAT Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. 17401363 2007