|
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Simian Immunodeficiency Viruses and HIV-2 are also restricted in PAF1 expressing cells.
|
22082156 |
2011 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Taken together, these findings link the tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein.
|
15923622 |
2005 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The <b>C</b><sub>iq</sub> cage was completely decomposed into free <b>L</b><sub>iq</sub> and [Pd(Cl)<sub>4</sub>]<sup>2-</sup> within 1 h. However, the <b>C</b><sub>q</sub> cage was more long lived and was only fully decomposed after 7 h. The new ligands (<b>L</b><sub>iq</sub> and <b>L</b><sub>q</sub>) and the Pd(II) cage architectures (<b>C</b><sub>iq</sub> and <b>C</b><sub>q</sub>) were assessed for their cytotoxic properties against two cancerous cell lines (A549 lung cancer and MDA-MB-231 breast cancer) and one non-cancerous cell line (HDFa skin cells).
|
30525025 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The <b>C</b><sub>iq</sub> cage was completely decomposed into free <b>L</b><sub>iq</sub> and [Pd(Cl)<sub>4</sub>]<sup>2-</sup> within 1 h. However, the <b>C</b><sub>q</sub> cage was more long lived and was only fully decomposed after 7 h. The new ligands (<b>L</b><sub>iq</sub> and <b>L</b><sub>q</sub>) and the Pd(II) cage architectures (<b>C</b><sub>iq</sub> and <b>C</b><sub>q</sub>) were assessed for their cytotoxic properties against two cancerous cell lines (A549 lung cancer and MDA-MB-231 breast cancer) and one non-cancerous cell line (HDFa skin cells).
|
30525025 |
2018 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The <b>C</b><sub>iq</sub> cage was completely decomposed into free <b>L</b><sub>iq</sub> and [Pd(Cl)<sub>4</sub>]<sup>2-</sup> within 1 h. However, the <b>C</b><sub>q</sub> cage was more long lived and was only fully decomposed after 7 h. The new ligands (<b>L</b><sub>iq</sub> and <b>L</b><sub>q</sub>) and the Pd(II) cage architectures (<b>C</b><sub>iq</sub> and <b>C</b><sub>q</sub>) were assessed for their cytotoxic properties against two cancerous cell lines (A549 lung cancer and MDA-MB-231 breast cancer) and one non-cancerous cell line (HDFa skin cells).
|
30525025 |
2018 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The <b>C</b><sub>iq</sub> cage was completely decomposed into free <b>L</b><sub>iq</sub> and [Pd(Cl)<sub>4</sub>]<sup>2-</sup> within 1 h. However, the <b>C</b><sub>q</sub> cage was more long lived and was only fully decomposed after 7 h. The new ligands (<b>L</b><sub>iq</sub> and <b>L</b><sub>q</sub>) and the Pd(II) cage architectures (<b>C</b><sub>iq</sub> and <b>C</b><sub>q</sub>) were assessed for their cytotoxic properties against two cancerous cell lines (A549 lung cancer and MDA-MB-231 breast cancer) and one non-cancerous cell line (HDFa skin cells).
|
30525025 |
2018 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The <b>C</b><sub>iq</sub> cage was completely decomposed into free <b>L</b><sub>iq</sub> and [Pd(Cl)<sub>4</sub>]<sup>2-</sup> within 1 h. However, the <b>C</b><sub>q</sub> cage was more long lived and was only fully decomposed after 7 h. The new ligands (<b>L</b><sub>iq</sub> and <b>L</b><sub>q</sub>) and the Pd(II) cage architectures (<b>C</b><sub>iq</sub> and <b>C</b><sub>q</sub>) were assessed for their cytotoxic properties against two cancerous cell lines (A549 lung cancer and MDA-MB-231 breast cancer) and one non-cancerous cell line (HDFa skin cells).
|
30525025 |
2018 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The 19q13 amplicon in pancreatic cancer cells contains a novel pancreatic differentiation 2 (PD2) gene (accession number AJ401156), which was identified by differential screening analysis.
|
16491129 |
2006 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
The 19q13 amplicon in pancreatic cancer cells contains a novel pancreatic differentiation 2 (PD2) gene (accession number AJ401156), which was identified by differential screening analysis.
|
16491129 |
2006 |
|
Hyperparathyroidism-Jaw Tumor Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a familial cancer syndrome that can result from germline inactivation of HRPT2/CDC73, a putative tumor suppressor gene that encodes parafibromin, a component of the transcriptional regulatory PAF1 complex with homology to the yeast protein Cdc73p.
|
20304979 |
2010 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The Pd(II) complexes have been tested for in vitro cytotoxicity activities against cancer cell line of K<sub>562</sub>.
|
28849726 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The Pd(II) complexes have been tested for in vitro cytotoxicity activities against cancer cell line of K<sub>562</sub>.
|
28849726 |
2018 |
|
Breast adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The activity results showed that, the Pd(II) complex of L has higher anti-tumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines.
|
29216566 |
2018 |
|
Adenocarcinoma of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
The activity results showed that, the Pd(II) complex of L has higher anti-tumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines.
|
29216566 |
2018 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The activity results showed that, the Pd(II) complex of L has higher anti-tumor effect than L and its Pt(II) complex against the tested human breast adenocarcinoma (MCF-7), human prostate adenocarcinoma (LNCAP), and human colon carcinoma (LS174T) cell lines.
|
29216566 |
2018 |
|
Peroxisome biogenesis disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The first, functional complementation, was established as a viable approach by Fujiki and colleagues, who identified PAF-1, the first known peroxisome biogenesis disorder gene.
|
8993569 |
1996 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The human PAF1 complex is linked to cancer, and in yeast, it has been reported to play a role in telomere biology.
|
29564528 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The human PAF1 complex is linked to cancer, and in yeast, it has been reported to play a role in telomere biology.
|
29564528 |
2018 |
|
Carcinogenesis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis.
|
16491129 |
2006 |
|
Leukemogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis.
|
29217648 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The new synthesized Pd(II) complexes <b>1</b> and <b>2</b> exhibit an important potential through their selective cytotoxic activity and by targeting the stem-like tumor cell populations, which leads to the tumor growth arrest and prevention of metastasis.
|
28358339 |
2017 |