|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the present study indicated that puerarin may exhibit antiapoptotic and anti-inflammatory activity through the PPARα pathway in rats with chronic heart failure.
|
31602208 |
2019 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study suggests that G-Rb3 is a promising agent and PPARα is potential target in the management of HF.
|
31577975 |
2019 |
|
Congestive heart failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that the left ventricular mass index (LVMI), collagen volume fraction (CVF), and free fatty acid (FFA) concentration of CHF group rats increased when compared with sham control group, while the protein and mRNA expressions of PPARα, MCAD, and MCPT1 decreased in CHF.
|
29301869 |
2018 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated whether Astragaloside IV can activate peroxisome proliferator-activated receptor alpha (PPARα) to stimulate fatty acid β-oxidation and increase cardiac energy production, improving mitochondrial function and the efficiency of SERCA in HF.
|
28578382 |
2017 |
|
Congestive heart failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of PPARs may be involved in the development of heart failure (HF).
|
29093735 |
2017 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study shows that fenofibrate may protect against ET-1-induced cardiomyocyte hypertrophy and enhanced adiponectin expression through modulation of PPARα expression in vitro and limitation of daunorubicin cardiotoxicity in vivo, suggesting a novel mechanistic insight into the role of PPARα and adiponectin in cardiac hypertrophy and heart failure.
|
27629528 |
2017 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies reported that heart failure develops in the heart of myosin heavy chain-PPAR-α transgenic mice in a manner similar to that of diabetic cardiomyopathy, whereas cardiac dysfunction is enhanced in PPAR-α knockout mice in response to chronic pressure overload.
|
28011586 |
2017 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nitric oxide synthase and PPARα exhibit sex differences and have also been proposed to mediate the development of hypertrophy and heart failure.
|
28158412 |
2017 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the changes in myocardial energy metabolism and the effect of peroxisome proliferator-activated receptor alpha/gamma (PPARα/γ) dual agonist TZD18 on myocardial energy metabolism in rats with heart failure after myocardial infarction.
|
29272013 |
2017 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we provide additional lines of evidence supporting the pathological involvement of the PPARα/Sirt1 complex in heart failure.
|
22333581 |
2012 |
|
Congestive heart failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the V162 allele of the human PPARA gene can be a new risk factor in the development of stage C heart failure, likely via depressed cardiac PPARα activity.
|
21430558 |
2011 |
|
Congestive heart failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PPAR transcriptional activator complex polymorphisms and the promise of individualized therapy for heart failure.
|
18998207 |
2010 |
|
Congestive heart failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the expression of the main genes involved in downstream pathway (peroxisome proliferator-activated receptor-alpha [PPAR-alpha] and both AMP-activated protein kinase-alpha1 and -alpha2 subunits) as well as their target genes in lipid (acyl-coenzyme A dehydrogenase C-14 to C-12 straight chain) and glucose metabolism (hexokinase-2) were significantly reduced in CHF.
|
20103776 |
2010 |
|
Congestive heart failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, a progressive decrease (p for trend<0.05) in the two PPARalpha target genes mRNA expression was observed among HT, LVH and HF groups.
|
16371224 |
2006 |
|
Congestive heart failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The peroxisome proliferator-activated receptor alpha (PPARalpha) is a central regulator of myocardial fatty acid (FA) metabolism implicated in the pathogenesis of heart failure.
|
16307905 |
2006 |
|
Congestive heart failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of peroxisome proliferator-activated receptor-alpha and -gamma in auricular tissue from heart failure patients.
|
16185925 |
2006 |