|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we use a new mouse model that targets deletion of the Ugt1 locus and the Ugt1a1 gene in liver to promote hyperbilirubinemia-induced seizures and central nervous system toxicity.
|
26480925 |
2016 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prolonged Hyperbilirubinemia in a Neonate with a Novel Mutation in the UDP-glucuronosyltransferase 1A1 Gene.
|
26859599 |
2016 |
|
Hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although Gilbert's syndrome is usually quite benign UGT1A1(TA)n genotyping is important in exclusion of more serious causes of hyperbilirubinemia and since it has significant implications for personalised medicine.
|
24785582 |
2014 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism UGT1A1*28 (*28)/*28 has been linked to an increased risk of hyperbilirubinemia in patients with CML who receive nilotinib.
|
23609856 |
2014 |
|
Hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nuclear factor κB down-regulates human UDP-glucuronosyltransferase 1A1: a novel mechanism involved in inflammation-associated hyperbilirubinaemia.
|
23130636 |
2013 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm UGT1A1 (TA)7 allele as one of the factors accounting for the hyperbilirubinemia and cholelithiasis observed in SCA and bTH.
|
24204915 |
2013 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tocilizumab-induced hyperbilirubinemia in Japanese patients with rheumatoid arthritis: its association with UDP glucuronosyltransferase 1A1 gene polymorphisms.
|
21993917 |
2012 |
|
Hyperbilirubinemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia.
|
21983082 |
2012 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variation of a short (TA)(n) repeat sequence (rs8175347) covering the TATA box of UGT1A1 (UDP-glucuronosyltransferase1A1) is associated with hyperbilirubinaemia (Gilbert's syndrome) and adverse drug reactions, and is used for dosage advice for irinotecan.
|
21309756 |
2011 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A prospective study was conducted to investigate the effects of birth body weight, sex, mode of delivery, glucose-6-phosphate dehydrogenase (G6PD) deficiency, variant UDP-glucuronosyltransferase 1A1 (UGT1A1) gene, and hepatic solute carrier organic anion transporter 1B1 (SLCO1B1) gene on hyperbilirubinemia in neonates who were breast-fed.
|
21592495 |
2011 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
UDP-glucuronosyltransferase 1A1 polymorphism, UGT1A1*28, which is associated with atazanavir-induced hyperbilirubinemia, is less common in Asians than in Caucasians.
|
20890421 |
2010 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic factors influencing severe atazanavir-associated hyperbilirubinemia in a population with low UDP-glucuronosyltransferase 1A1*28 allele frequency.
|
20504240 |
2010 |
|
Hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adult Tg(UGT1(A1*28))Ugt1(-/-) mice expressed elevated levels of total bilirubin (TB) compared with Tg(UGT1(A1*1))Ugt1(-/-) mice, confirming that the promoter polymorphism associated with the UGT1A1*28 allele contributes to hyperbilirubinemia in mice.
|
20194756 |
2010 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
(TA)7 promoter polymorphism in the gene encoding the bilirubin conjugating enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) potentiates hyperbilirubinemia in G-6-PD deficient neonates.
|
18043502 |
2008 |
|
Hyperbilirubinemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir.
|
16609363 |
2006 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A case-control study was designed to investigate the effects of eight known risk factors [breast feeding, ABO incompatibility, premature birth, infection, cephalohematoma, asphyxia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and variant UDP-glucuronosyltransferase 1A1 (UGT1A1) gene] and a suspicious analog [organic anion transporter 2 (OATP 2) gene] on severe hyperbilirubinemia in Taiwanese neonates.
|
15319464 |
2004 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This finding indicates that the variant promoter of UGT-1 A does not contribute to the development of hyperbilirubinemia in the newborn.
|
10541948 |
1999 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Elucidation of both the structure of the UGT1 gene complex, and the Mrp2 (cMoat) gene which encodes the canalicular conjugate export pump, has led to a greater understanding of the genetic basis of hyperbilirubinemia.
|
9748558 |
1998 |
|
Hyperbilirubinemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, recombinant adenoviral vectors were used to demonstrate in vivo complementation of the genetic defect in Gunn rat livers with the HUG Br1 cDNA leading to a resolution of hyperbilirubinemia lasting approximately 7 weeks.
|
9156798 |
1996 |