|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.
|
24681603 |
2014 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the role of PPARδ in colon cancer cells in a hypoxic tumor microenvironment is not fully understood.
|
24610641 |
2014 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
The putative impact of TFA on colon cancer development with respect to PPARδ activation is being discussed.
|
23368924 |
2013 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: how to aim?
|
23041232 |
2013 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model.
|
23593291 |
2013 |
|
Malignant tumor of colon
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Specific knockdown of PPARδ gene in colon cancer cells by lentivirus-mediated RNA interfering.
|
23100225 |
2013 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Stable over-expression of PPARβ/δ in human colon cancer cell lines enhanced ligand activation of PPARβ/δ and inhibition of clonogenicity in HT29 cells.
|
21400612 |
2011 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these findings consistently indicate that PPAR-beta may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer, having a role as an inhibitor in the carcinogenesis and progression of colorectal cancer.
|
19935699 |
2010 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NSAIDs inhibited cell growth in RKO (wild-type APC) and DLD1 (mutant APC) human colon cancer cell lines but expression of PPAR beta/delta was not downregulated in these cell lines in response to a broad concentration range of celecoxib, indomethacin, NS-398, or nimesulide.
|
19415698 |
2009 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is evidence that they induce colon cancer cell apoptosis by suppressing peroxisome proliferator-activated receptor delta (PPARdelta) through inhibition of COX-2-derived prostacyclin (PGI2).
|
19347284 |
2009 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
To directly establish the role of PPAR-delta in colon cancer development and progression, we selected high-affinity RNA aptamers and expressed them in several colon cancer cell lines.
|
19723884 |
2009 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-delta (PPAR-delta) is overexpressed in human colon cancer, but its contribution to colonic tumorigenesis is controversial.
|
19436036 |
2009 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
In view of the association of PPARbeta with colon cancer and increased mRNA levels of PPARbeta in colon tumours we sought in this study to examine the expression of PPARbeta in human breast epithelial cells of tumorigenic (MCF-7 and MDA-MB-231) and non-tumorigenic origin (MCF-10A).
|
12009300 |
2002 |