Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the role of PPARδ in colon cancer cells in a hypoxic tumor microenvironment is not fully understood.
|
24610641 |
2014 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.
|
24681603 |
2014 |
Colon Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Specific knockdown of PPARδ gene in colon cancer cells by lentivirus-mediated RNA interfering.
|
23100225 |
2013 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The putative impact of TFA on colon cancer development with respect to PPARδ activation is being discussed.
|
23368924 |
2013 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model.
|
23593291 |
2013 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: how to aim?
|
23041232 |
2013 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Stable over-expression of PPARβ/δ in human colon cancer cell lines enhanced ligand activation of PPARβ/δ and inhibition of clonogenicity in HT29 cells.
|
21400612 |
2011 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these findings consistently indicate that PPAR-beta may facilitate differentiation and inhibit the cell-fibronectin adhesion of colon cancer, having a role as an inhibitor in the carcinogenesis and progression of colorectal cancer.
|
19935699 |
2010 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NSAIDs inhibited cell growth in RKO (wild-type APC) and DLD1 (mutant APC) human colon cancer cell lines but expression of PPAR beta/delta was not downregulated in these cell lines in response to a broad concentration range of celecoxib, indomethacin, NS-398, or nimesulide.
|
19415698 |
2009 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To directly establish the role of PPAR-delta in colon cancer development and progression, we selected high-affinity RNA aptamers and expressed them in several colon cancer cell lines.
|
19723884 |
2009 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is evidence that they induce colon cancer cell apoptosis by suppressing peroxisome proliferator-activated receptor delta (PPARdelta) through inhibition of COX-2-derived prostacyclin (PGI2).
|
19347284 |
2009 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-delta (PPAR-delta) is overexpressed in human colon cancer, but its contribution to colonic tumorigenesis is controversial.
|
19436036 |
2009 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In view of the association of PPARbeta with colon cancer and increased mRNA levels of PPARbeta in colon tumours we sought in this study to examine the expression of PPARbeta in human breast epithelial cells of tumorigenic (MCF-7 and MDA-MB-231) and non-tumorigenic origin (MCF-10A).
|
12009300 |
2002 |