PPBP, pro-platelet basic protein, 5473

N. diseases: 111; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.310 Biomarker disease BEFREE In this study, we investigated the serum level of CTAPIII/CXCL7 in patients at different stage of lung cancer and the diagnostic efficacy of CTAPIII/CXCL7 in NSCLC. 29356357 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.310 Biomarker disease CTD_human Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. 27935865 2017
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.300 Biomarker group CTD_human Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. 27935865 2017
CUI: C0020517
Disease: Hypersensitivity
Hypersensitivity
0.300 Biomarker group CTD_human Evaluation of selected biomarkers for the detection of chemical sensitization in human skin: a comparative study applying THP-1, MUTZ-3 and primary dendritic cells in culture. 23624239 2013
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction
0.300 Biomarker phenotype CTD_human Evaluation of selected biomarkers for the detection of chemical sensitization in human skin: a comparative study applying THP-1, MUTZ-3 and primary dendritic cells in culture. 23624239 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group CTD_human Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy. 15513305 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker group CTD_human Increased beta-thromboglobulin in essential hypertension: interactions between arterial plasma adrenaline, platelet function and blood lipids. 6192689 1983
MRSA - Methicillin resistant Staphylococcus aureus infection
0.060 Biomarker disease BEFREE The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. 30858202 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 Biomarker group BEFREE AMD3100 (a chemokine (C-X-C motif) receptor 4 antagonist) and an anti-chemokine (C-X-C motif) ligand 7 antibody were used to block the tumor-supporting capacity of cancer-associated fibroblasts. 28475003 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 Biomarker group BEFREE Three protein peaks (m/z 12,138, m/z 13,462, and m/z 15,120) that were significantly upregulated in the tumor tissue were identified as macrophage migration inhibitory factor (MIF), chemokine (C-X-C motif) ligand 7 (CXCL7), and interleukin 25 (IL-25). 28188039 2017
MRSA - Methicillin resistant Staphylococcus aureus infection
0.060 Biomarker disease BEFREE Confirmation of methicillin-resistant Staphylococcus aureus (MRSA) was performed using multiplex PCR targeting mecA and nuc genes in addition to phenotypic assay based on PBP-2a latex agglutination. 26178302 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 Biomarker group BEFREE CXCL7 antibodies strongly reduced the growth of ccRCC tumors in nude mice. 24335961 2014
MRSA - Methicillin resistant Staphylococcus aureus infection
0.060 GeneticVariation disease BEFREE In this study, two clonal complex 130 (CC130) methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients in Irish hospitals were identified that were phenotypically PBP 2a positive but lacked mecA by conventional PCR and by DNA microarray screening. 21636525 2011
MRSA - Methicillin resistant Staphylococcus aureus infection
0.060 Biomarker disease BEFREE Phenotypically identified methicillin resistant Staphylococcus aureus (MRSA) strains from several hospitals in Romania and Saudi Arabia (n = 103 and 68, respectively) were confirmed to be MRSA by mecA PCR and PBP-2' based latex agglutination. 16168939 2005
MRSA - Methicillin resistant Staphylococcus aureus infection
0.060 Biomarker disease BEFREE The present study compared the MRSA-Screen latex agglutination test (Denka Seiken Co., Ltd., Tokyo, Japan) for detection of PBP 2a with agar dilution, the VITEK-1 and VITEK-2 systems (bioMérieux, St. Louis, Mo.), and the oxacillin agar screen test for detection of MRSA, with PCR for the mecA gene used as the "gold standard" assay. 11682512 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 AlteredExpression group BEFREE Increased serum levels of beta-thromboglobulin and platelet factor 4 indicated that platelets were destroyed and consumed within the vascular bed of the tumor. 10321640 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 Biomarker group BEFREE Our results, coupled with tumor suppression assays in G401 WT cells, do not support a role for NAP-2 in the etiology of WT. 9325046 1997
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 AlteredExpression group BEFREE Exposure of UT-7 to the tumor promoter, phorbol myristate acetate (PMA), resulted in the appearance of mature megakaryocytic properties, including the expression of platelet factor 4 and beta-thromboglobulin. 8439961 1993
MRSA - Methicillin resistant Staphylococcus aureus infection
0.060 Biomarker disease BEFREE Moreover, a 4.3 kb HindIII fragment containing MRSA-PBP gene was detected by using the same oligonucleotide probe. 2048117 1991
CUI: C0021400
Disease: Influenza
Influenza
0.050 GeneticVariation disease BEFREE Molecular diagnosis and characterization of a culture-negative mycotic aneurysm due to ST54 Haemophilus influenzae type b with PBP 3 alterations. 29373266 2018
CUI: C0021400
Disease: Influenza
Influenza
0.050 GeneticVariation disease BEFREE It is suggest that the minimum bactricidal concentration (MBC) was dissociated from the minimum inhibitory concentration (MIC) in S. pneumoniae and H. influenzae with abnormal pbp genes. 17109098 2006
CUI: C0021400
Disease: Influenza
Influenza
0.050 GeneticVariation disease BEFREE High prevalence of penicillin-binding protein (PBP) gene mutated (PGM) strains of H. influenzae should be taken into account when treating otitis media in children. 16428188 2006
CUI: C0021400
Disease: Influenza
Influenza
0.050 Biomarker disease BEFREE Non-beta-lactamase-producing ampicillin-resistant (BLNAR) strains with mutations in penicillin-binding protein (PBP) genes of Haemophilus influenzae have been prevalent recently among younger children. 15880950 2005
CUI: C0021400
Disease: Influenza
Influenza
0.050 Biomarker disease BEFREE The penicillin binding protein (PBP) genes dacA, dacB and ftsI from 14 cefuroxime-resistant (CXM(R)) isolates and three clinical isolates with low CXM MIC for non-beta-lactamase-producing Haemophilus influenzae type b were molecularly characterized. 12615852 2003
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.040 Biomarker disease BEFREE WBC, CRP and IL-6 as inflammation parameters and MPV and β-TG as platelet biomarkers may be useful indicators of the presence of coronary artery disease. 30505168 2018