TET2, tet methylcytosine dioxygenase 2, 54790

N. diseases: 362; N. variants: 47
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease BEFREE Deletion of Tet2 in murine melanoma and colon tumor cells reduced chemokine expression and TILs, enabling tumors to evade anti-tumor immunity and to resist anti-PD-L1 therapy. 31310587 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease BEFREE We conclude that TET2 acts as a barrier to melanoma initiation and progression, partly by promoting 5hmC gains in specific gene bodies. 30538121 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.150 AlteredExpression disease BEFREE We found that Tet2 expression is increased in intratumoral myeloid cells both in mouse models of melanoma and in melanoma patients and that this increased expression is dependent on an IL-1R-MyD88 pathway. 28813659 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.150 GeneticVariation disease BEFREE This study is the first to implicate TET2 genetic variation and mutation in melanoma. 24980573 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.150 GeneticVariation disease GWASCAT Identification of a melanoma susceptibility locus and somatic mutation in TET2. 24980573 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.150 GeneticVariation disease GWASDB Identification of a melanoma susceptibility locus and somatic mutation in TET2. 24980573 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease BEFREE It is suggested that 5hmC and TET2 possibly play an important role in the epigenetic regulation of melanoma development and progression. 23458759 2013