|
Abdominal Cramps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The main action consists in the blockade of Ca2+ entry through L-type Ca2+ channels and interference with intracytoplasmatic Ca2+ mobilization necessary for SMC contraction, thus preventing excessive bowel contractions and abdominal cramps.
|
29732965 |
2018 |
|
Abdominal Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Further, OB blocks the T-type Ca2+ channels and interferes with the muscarinic responses; it interacts, directly or indirectly, with the tachykinin receptors on SMC and on primary afferent neurons whose combined effects may result in the reduction of motility and abdominal pain.
|
29732965 |
2018 |
|
Abnormality of epiphysis morphology
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the ilium
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the metaphysis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the wrist
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acquired Camptodactyly
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our machine learning models trained on the morphometric and connectome estimates (number of features = 34,646) showed optimal classification accuracy (AD/SMC: 97% accuracy, MCI/SMC: 83% accuracy; AD/MCI: 97% accuracy) in NHIS-IH cohort, outperforming a benchmark model (FLAIR-based white matter hyperintensity volumes).
|
31150957 |
2019 |
|
Anaplasia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
OSA-induced cardiovascular fibrosis was associated with SMC dedifferentiation, and PHD3 overexpression may benefit its prevention by reversing the dedifferentiation.
|
31346526 |
2019 |
|
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
HERP1 expression was associated with the SMC proliferation and dedifferentiation in vitro and in vivo.
|
16151017 |
2005 |
|
Angelman Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Case report: Angelman syndrome in an individual with a small SMC(15) and paternal uniparental disomy: a case report with reference to the assessment of cognitive functioning and autistic symptomatology.
|
12757356 |
2003 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that IgE actives the lincRNAp21-p21 pathway to induce SMC senescence, which contributes to the formation of AAA, and lincRNA-p21 is a potential therapeutic target for AAA aggravated by asthma.
|
31440377 |
2019 |
|
Arterial aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate that mast cells participate in AAA pathogenesis in mice by releasing proinflammatory cytokines IL-6 and IFN-gamma, which may induce aortic SMC apoptosis, matrix-degrading protease expression, and vascular wall remodeling, important hallmarks of arterial aneurysms.
|
17932568 |
2007 |
|
Arteriopathic disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Human MYH11 gene mutations provide the first example of a direct change in a specific SMC protein leading to an inherited arterial disease.
|
16444274 |
2006 |
|
Arteriosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analyzed expression patterns of genes involved in carotid atherosclerosis development (e.g., transcription factors of regulation of SMC genes) of VSMCs located inside or outside the plaque lesion that may give clues about changes in phenotypic plasticity during atherosclerosis.
|
29562638 |
2018 |
|
Arteriosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, SMC-targeted GLUT1 overexpression fails to accelerate atherosclerosis in mice that do not exhibit the metabolic syndrome phenotype or monocytosis.
|
29875324 |
2018 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition to typical smooth muscle cell (SMC) markers, these pathways also encompassed cytoskeleton-related genes previously not associated with atherosclerosis.
|
27470516 |
2016 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study suggests that IgE actives the lincRNAp21-p21 pathway to induce SMC senescence, which contributes to the formation of AAA, and lincRNA-p21 is a potential therapeutic target for AAA aggravated by asthma.
|
31440377 |
2019 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Paracrine signaling from lung epithelium to the surrounding mesenchyme is important for lung SMC development and function and is a contributing factor in an array of pulmonary diseases such as bronchopulmonary dysplasia, pulmonary hypertension, and asthma.
|
19690384 |
2009 |
|
Atherosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, SMC-targeted GLUT1 overexpression fails to accelerate atherosclerosis in mice that do not exhibit the metabolic syndrome phenotype or monocytosis.
|
29875324 |
2018 |
|
Atherosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analyzed expression patterns of genes involved in carotid atherosclerosis development (e.g., transcription factors of regulation of SMC genes) of VSMCs located inside or outside the plaque lesion that may give clues about changes in phenotypic plasticity during atherosclerosis.
|
29562638 |
2018 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
In addition to typical smooth muscle cell (SMC) markers, these pathways also encompassed cytoskeleton-related genes previously not associated with atherosclerosis.
|
27470516 |
2016 |
|
Atherosclerotic lesion
|
0.010 |
Biomarker
|
disease |
BEFREE |
SMC-specific deletion of Noxa1 in Apoe<sup>-/-</sup> mice (Noxa1<sup>SMC-/-</sup>/Apoe<sup>-/-</sup>) similarly decreased vascular ROS levels and atherosclerotic lesion size.
|
30576919 |
2019 |
|
Atlantoaxial instability
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Attention deficit hyperactivity disorder
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|