|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our machine learning models trained on the morphometric and connectome estimates (number of features = 34,646) showed optimal classification accuracy (AD/SMC: 97% accuracy, MCI/SMC: 83% accuracy; AD/MCI: 97% accuracy) in NHIS-IH cohort, outperforming a benchmark model (FLAIR-based white matter hyperintensity volumes).
|
31150957 |
2019 |
|
Presenile dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Efforts to minimize childhood poverty may diminish or delay the onset of SMC and dementia in later life.
|
31317850 |
2019 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that HCV modulates the function of the Structural Maintenance of Chromosome (SMC) protein complex, cohesin, which tethers remote regions of chromatin.
|
30698808 |
2019 |
|
synovial sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We confirmed that TGF-β1 expression in ECs could influence SMC phenotypic change under SS conditions and that TGF-β1 expression in ECs could also change MMP-2 production but not MMP-9 production in SMCs under SS conditions in the co-culture model.
|
30707337 |
2019 |
|
Sweet Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We confirmed that TGF-β1 expression in ECs could influence SMC phenotypic change under SS conditions and that TGF-β1 expression in ECs could also change MMP-2 production but not MMP-9 production in SMCs under SS conditions in the co-culture model.
|
30707337 |
2019 |
|
Depressive Symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These findings suggest that the MIND diet could help to prevent or delay SMC among older adults without depressive symptoms.
|
30706155 |
2019 |
|
Sicca Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We confirmed that TGF-β1 expression in ECs could influence SMC phenotypic change under SS conditions and that TGF-β1 expression in ECs could also change MMP-2 production but not MMP-9 production in SMCs under SS conditions in the co-culture model.
|
30707337 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that IgE actives the lincRNAp21-p21 pathway to induce SMC senescence, which contributes to the formation of AAA, and lincRNA-p21 is a potential therapeutic target for AAA aggravated by asthma.
|
31440377 |
2019 |
|
Muscular stiffness
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Consistently, in vitro studies confirmed that stiff surface induced SMC genes whereas soft surface induced glial genes.
|
30368818 |
2019 |
|
Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Efforts to minimize childhood poverty may diminish or delay the onset of SMC and dementia in later life.
|
31317850 |
2019 |
|
Sleep Apnea, Obstructive
|
0.010 |
Biomarker
|
disease |
BEFREE |
OSA-induced cardiovascular fibrosis was associated with SMC dedifferentiation, and PHD3 overexpression may benefit its prevention by reversing the dedifferentiation.
|
31346526 |
2019 |
|
Atherosclerotic lesion
|
0.010 |
Biomarker
|
disease |
BEFREE |
SMC-specific deletion of Noxa1 in Apoe<sup>-/-</sup> mice (Noxa1<sup>SMC-/-</sup>/Apoe<sup>-/-</sup>) similarly decreased vascular ROS levels and atherosclerotic lesion size.
|
30576919 |
2019 |
|
Abdominal Cramps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The main action consists in the blockade of Ca2+ entry through L-type Ca2+ channels and interference with intracytoplasmatic Ca2+ mobilization necessary for SMC contraction, thus preventing excessive bowel contractions and abdominal cramps.
|
29732965 |
2018 |
|
Abdominal Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Further, OB blocks the T-type Ca2+ channels and interferes with the muscarinic responses; it interacts, directly or indirectly, with the tachykinin receptors on SMC and on primary afferent neurons whose combined effects may result in the reduction of motility and abdominal pain.
|
29732965 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated 226 cases of breast cancer from Kangbuk SMC between 2000 and 2005.
|
29482985 |
2018 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, this is the first study demonstrating CDC25C and Cyclin B1 proteins could be used as potential target for anticancer therapy and DMC may be explored as new therapeutic agent in the cure of Glioblastoma (GBM).
|
30009775 |
2018 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study was designed to elucidate the DMC induced mechanism of cell cycle arrest in human glioma U87 MG cells.
|
30009775 |
2018 |
|
Hyperlipidemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent with this, en face analyses displayed a marked increase in α-SMC-positive endothelial cells in SIRT3<sup>-/-</sup> mice with acute hyperlipidaemia.
|
29277324 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC's action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer.
|
30076727 |
2018 |
|
Psychotic Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Although the symptoms of schizophrenia and related psychoses are known to affect decision-making capacity for treatment (DMC-T), we know little about their effect on DMC-R.AimsWe aimed to determine if DMC-R differs from DMC-T in proportion and associated symptoms in an in-patient sample of people with schizophrenia and related psychoses.
|
29909778 |
2018 |
|
Monocytosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, SMC-targeted GLUT1 overexpression fails to accelerate atherosclerosis in mice that do not exhibit the metabolic syndrome phenotype or monocytosis.
|
29875324 |
2018 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC's action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer.
|
30076727 |
2018 |
|
Metabolic Syndrome X
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, SMC-targeted GLUT1 overexpression fails to accelerate atherosclerosis in mice that do not exhibit the metabolic syndrome phenotype or monocytosis.
|
29875324 |
2018 |
|
Carotid Atherosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we analyzed expression patterns of genes involved in carotid atherosclerosis development (e.g., transcription factors of regulation of SMC genes) of VSMCs located inside or outside the plaque lesion that may give clues about changes in phenotypic plasticity during atherosclerosis.
|
29562638 |
2018 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC's action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer.
|
30076727 |
2018 |