PPID, peptidylprolyl isomerase D, 5481

N. diseases: 72; N. variants: 2
Disease: Pancreatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.020 Biomarker disease BEFREE •Pancreatitis-inducing factors open the membrane transition pore (mPTP) channel via cyclophilin D activation in acinar cells, causing calcium overload and cell death; genetic or pharmacological inhibition of mPTP improves the outcome of acute pancreatitis in animal models. 31631343 2019
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.020 Biomarker disease BEFREE Pancreatitis was induced in C57BL/6J mice (control) and mice deficient in peptidylprolyl isomerase D (cyclophilin D, encoded by Ppid) by administration of L-arginine (also in rats), caerulein, bile acid, or an AP-inducing diet. 29074451 2018