Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
Healthy lifestyle intervention may be beneficial for women with the GDM predisposing CDKAL1 genetic variant in improvement of insulin resistance.
|
31542245 |
2019 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
14 eligible studies were included.CDKAL1 rs7754840 and rs7756992 showed significant correlation with GDM risk under the allele, recessive, dominant, homozygote and heterozygote models.
|
30074065 |
2018 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
The most important risk alleles associated with GDM were rs10830963/G of MTNR1B (OR = 1.84/1.64 [IADPSG/m'99WHO], p = 0.0007/0.006), rs7754840/C (OR = 1.51/NS, p = 0.016) of CDKAL1 and rs1799884/T (OR = 1.4/1.56, p = 0.04/0.006) of GCK.
|
28072873 |
2017 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of this study was to examine the association between GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 gene polymorphisms and the development of gestational diabetes.
|
28359772 |
2017 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
The rs7754840 and rs7756992 SNPs of the CDKAL1 gene were found to be associated with GDM in this south Indian population.
|
25723968 |
2015 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (rs5219" genes_norm="3767">E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (rs1801278" genes_norm="3667">Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk.
|
23029294 |
2012 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study of gestational diabetes mellitus in Korean women.
|
22233651 |
2012 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide association study of gestational diabetes mellitus in Korean women.
|
22233651 |
2012 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
Two loci known to be associated with type 2 diabetes had a genome-wide significant association with GDM in the joint analysis. rs7754840, a variant in CDKAL1, had the strongest association with GDM (odds ratio 1.518; P=6.65×10(-16)).
|
22233651 |
2012 |
Gestational Diabetes
|
0.190 |
GeneticVariation
|
phenotype |
BEFREE |
The risk alleles of the SNPs rs7756992 and rs7754840 in CDKAL1; rs10811661 in the CDKN2A-CDKN2B region; and rs1111875, rs5015480 and rs7923837 in HHEX were associated with significant decreases in the insulin AUC during a 100 g OGTT performed at the time of diagnosis of GDM.
|
19002430 |
2009 |