|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ecto-5'-nucleotidase (NT5E/CD73) is a pivotal regulator of tumor migration and has angiogenetic properties.
|
29916747 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ecto-5'-nucleotidase CD73 plays an important role in the production of immune-suppressive adenosine in tumor micro-environment, and has become a validated drug target in oncology.
|
29377887 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Detection of high-grade neoplasia in air-dried cervical PAP smears by a microRNA-based classifier.
|
29328473 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Given PAP's expression in the brain and its role as a cell-growth regulator and tumor suppressor, our results have important implications in brain health such as cancer and other brain diseases including neurodegenerative diseases (e.g., Alzheimer's disease and Parkinson's disease) and mental health (e.g., anxiety, depression, and schizophrenia).
|
27357282 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model.
|
26491983 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also investigated the in vivo therapeutic effects of multiple PAP-fused cytokines in a mouse prostate cancer model bearing prostate-specific antigen (PSA)- and PAP-expressing tumors.
|
25632844 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor.
|
24747769 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have shown that Abs that target the cell-surface enzyme CD73 (ecto-5'-nucleotidase) reduce growth of primary tumors and metastasis in syngenic mice by inhibiting the catalytic activity of CD73, and thus increasing the activity of cytotoxic T lymphocytes.
|
24043904 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The lack of substance P and acidic fibroblast growth factor immunoreactivity; the low immunohistochemical expression of CDX2, vesicular monoamine transporter 1, connective tissue growth factor, and prostatic acid phosphatase; the lack of S100-positive sustentacular cells; the strong expression of vesicular monoamine transporter 2; and peculiar ultrastructural features characterize pancreatic EC cell tumors and differentiate them from intestinal ones, although both categories show similar chromosome 18 cytogenetic alterations.
|
21705949 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that serum PAP is a useful tumor marker for intravascular LBCL and that it deserves further investigation in this context.
|
15371956 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We subsequently investigated the growth suppression effect of PAcP cDNA intratumoral injection in pre-established C-81 xenograft tumors, and analyzed the expression of PAcP, prostate-specific antigen (PSA), proliferating cell nuclear antigen (PCNA), and c-ErbB-2 in the tumors by immunohistochemistry and Western blotting.
|
12712404 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Prostatic acid phosphatase has served as a tumor marker for metastatic prostate cancer for many years.
|
11414767 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There is a positive association between ER alpha, ER beta, and PGR expression (P < 0.0001) and a negative association between AR and the androgen-regulated gene PAP expression in hormone-refractory tumors.
|
11280747 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Prostatic acid phosphatase and prostate-specific antigen were retained during serial transplantation in all tumors but the PC-324 and PC-339.
|
8780407 |
1996 |