ATG16L1, autophagy related 16 like 1, 55054

N. diseases: 120; N. variants: 31
Disease: Bacterial Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.030 Biomarker group BEFREE Such alteration impairs the unconventional autophagic activity of TMEM59, a transmembrane protein that contains the WD40 domain-binding motif, and disrupts its normal intracellular trafficking and its ability to engage ATG16L1 in response to bacterial infection. 27273576 2016
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.030 Biomarker group BEFREE NOD2 and ATG16L1 are among the major CD susceptibility genes implicated in impaired immune response to bacterial infection. 23850724 2013
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.030 Biomarker group BEFREE ATG16L1 also plays a crucial role in maintaining Paneth cell function and morphology, while IRGM seems to be associated with mitochondrial function and apoptosis.Dysfunction of these molecules, i.e. of autophagy in vivo, is clearly associated with the increased bacterial infection and the onset of colitis. 23295687 2012