|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using the National Health Insurance claims data, we collected data on patients diagnosed with IBD [10,049 with ulcerative colitis (UC) and 5595 with Crohn's disease (CD)] from 2011 to 2014.
|
28593437 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1 gene was genotyped for ten different SNPs using DNA extracted from peripheral blood of 234 patients with Crohn's disease (CD), 249 patients with ulcerative colitis (UC) and 393 healthy controls The SNPs rs2241880, rs4663396, rs3792106, rs10210302, rs3792109, rs2241877, rs6737398, rs11682898, rs4663402 and rs4663421 were genotyped using the Sequenom MassArray platform.
|
28542425 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Clinically, the ATG16L1 risk variant associated with increased response to thiopurine treatment in patients with Crohn's disease but not ulcerative colitis.
|
27435106 |
2017 |
|
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
ATG16L1 and LC3 expression was analyzed in the inflamed ileum and colon of 28 patients with Crohn's disease (CD), 14 with ulcerative colitis (UC) and 23 controls by western blot.
|
27335178 |
2016 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Epistasis analysis showed weak epistasis between the ATG16L1 SNP rs2241879 and PTPN2 SNP rs2542151 (p = 0.024) in CD and between ATG16L1 SNP rs4663396 and PTPN2 SNP rs7234029 (p = 4.68×10⁻³) in UC.
|
22457781 |
2012 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD.
|
20222171 |
2010 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
One hundred and eighty unrelated IBD patients [57 Crohn's disease (CD) and 123 ulcerative colitis (UC)] and 186 healthy controls were genotyped for the following known genetic susceptibility variants: NOD2 - Arg702Trp (rs2066844), rs2066845" genes_norm="64127">Gly908Arg (rs2066845) and Leu1007insC (rs2066847), as well as IL23R - rs11209026;rs901312933" genes_norm="149233;55054">Arg381Gln (rs11209026) and ATG16L1 - rs2241880;s2241880;rs1384936174" genes_norm="55054;64127">Thr300Ala (rs2241880).
|
20082483 |
2010 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We confirm the association of CD with variants in the IL-23R and ATG16L1 genes and the more modest association of the IL-23R R381Q variant with UC.
|
19276991 |
2009 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC.
|
19491842 |
2009 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
With the recent completion of the human genome project, whole genome association studies (WGAS) have now become possible and have identified additional genes (IL23R, IRGM, PTGER4, ATG16L1) for Crohn's disease and ulcerative colitis, that have subsequently been replicated.
|
18473763 |
2008 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Crohn's disease, but not ulcerative colitis, is associated with genetic variation in NOD2 and an autophagy gene, ATG16L1, both of which affect the intracellular processing of bacterial components.
|
18500230 |
2008 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Five hundred eighteen Dutch white IBD patients (311 CD and 207 UC, including 176 trios of patients with both parents), 508 celiac disease patients, and 893 healthy controls were studied for association with the rs11209026 (IL23R) and rs2241880 (ATG16L1) single nucleotide polymorphisms (SNP).
|
18047540 |
2008 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IL23R was associated with CD and UC only in the absence of CARD15 mutations, whereas ATG16L1 was associated with CD in the presence and absence of CARD15 mutations.
|
17894849 |
2007 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1 risk genotype showed a modest but significant association with ulcerative colitis (P = .026).
|
17484864 |
2007 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
LHGDN |
The ATG16L1 risk genotype showed a modest but significant association with ulcerative colitis (P = .026).
|
17484864 |
2007 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Seventeen steroid-dependent consecutive patients with IBD (10 UC mean age 36 +/- 12, and 7 Crohn's disease mean age 31 +/- 5) were consecutively recruited.
|
16494108 |
2006 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Twenty one patients with IBD (10 with ulcerative colitis (UC), 11 with Crohn's disease (CD)), seven disease specificity controls (DSC), and seven healthy controls were studied.
|
11171821 |
2001 |