ATG16L1, autophagy related 16 like 1, 55054

N. diseases: 120; N. variants: 31
Disease: Ileitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020877
Disease: Ileitis
Ileitis 		0.020 GeneticVariation disease BEFREE In contrast to a protective role of the IRE1β isoform, hyperactivated IRE1α also drives a similar ileitis developing earlier in life in Atg16l1;Xbp1<sup>ΔIEC</sup> mice, in which ER stress is induced by deletion of the unfolded protein response transcription factor XBP1. 28082357 2017
CUI: C0020877
Disease: Ileitis
Ileitis 		0.020 AlteredExpression disease BEFREE The transcriptional regulation of ATG16L1 was studied in intestinal epithelial cells following stimulation with Toll-like receptor (TLR) ligands and proinflammatory cytokines and in a murine ileitis model and CD biopsies. 18162085 2008