ATG16L1, autophagy related 16 like 1, 55054

N. diseases: 120; N. variants: 31
Disease: Inflammatory Bowel Disease 10 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. 25645662 2016
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. 27273576 2016
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT Autophagy genes variants and paediatric Crohn's disease phenotype: a single-centre experience. 24656308 2014
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. 24553140 2014
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. 18985712 2009
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children. 19659808 2009
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients. 18499543 2008
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. 18047540 2008
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 Biomarker disease MGD A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. 18849966 2008
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 17435756 2007
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. 17200669 2007
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 GeneticVariation disease UNIPROT A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. 17484864 2007
CUI: C1970207
Disease: Inflammatory Bowel Disease 10
Inflammatory Bowel Disease 10 		0.700 Biomarker disease CTD_human