SLC52A1, solute carrier family 52 member 1, 55065

N. diseases: 160; N. variants: 0
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE PAR2 mediated tryptase-induced cell migration and might contribute to the invasion of cancer cells at the edge of tumor. 31598400 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE In parallel, when a truncated PAR2 was utilized in a xenograft mouse model, it inhibited PAR1-PAR2-driven tumor growth in vivo. 24177339 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE PAR-2 histoscores and mRNA levels significantly (P < 0.05) increased in 12 of 30 metastatic lymph node lesions from the corresponding primary tumor. 18937843 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE In contrast, palpable tumors and multifocal disease developed slower in PAR2(-/-) mice, and as a consequence of delayed tumor onset, metastasis was reduced. 18757438 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Thus, our results provide early experimental evidence for a tumor-protective role of PAR(2). 17476297 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE PAR-1 and PAR-2 in the cells forming the tumor microenvironment suggest that these receptors mediate the signaling of secreted thrombin and trypsin in the processes of cellular metastasis. 11395381 2001