|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis.
|
30154412 |
2018 |
|
Carcinogenesis
|
0.060 |
PosttranslationalModification
|
phenotype |
BEFREE |
ARD1-dependent PGK1 acetylation and PGK1-mediated Beclin1 S30 phosphorylation are required for glutamine deprivation- and hypoxia-induced autophagy and brain tumorigenesis.
|
28238651 |
2017 |
|
Carcinogenesis
|
0.060 |
GeneticVariation
|
phenotype |
BEFREE |
In the present study, we demonstrated that mARD1(225), mARD1(235), and hARD1(235) have conserved autoacetylation activities, and that they selectively regulate distinct roles of ARD1 variants in tumorigenesis.
|
25338643 |
2015 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Because AR-ARD1 interaction facilitated the AR binding to its targeted promoters for gene transcription, we propose that ARD1 functions as a unique AR regulator and forms a positive feedback loop for AR-dependent prostate tumorigenesis.
|
22315407 |
2012 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
To explore the clinical and pathological significance of ARD1 in breast tumorigenesis, we analyzed ARD1 status in multiple types of breast disease.
|
22292636 |
2011 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
|
20145209 |
2010 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
ARD1 prevents mTOR activity and breast cancer cell growth by stabilizing tuberous sclerosis complex 2 (TSC2) to induce autophagy.
|
30154412 |
2018 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
ARD1 prevents mTOR activity and breast cancer cell growth by stabilizing tuberous sclerosis complex 2 (TSC2) to induce autophagy.
|
30154412 |
2018 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We hope that, by providing new insights into ARD1, this review will help to guide the next steps in the development of markers for the early detection and prognosis of HCC.
|
30054466 |
2018 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We first conducted a study with 106 cases to explore the association of NIPP1 and/or enhancer of zeste homolog 2 (EZH2) expression with poor prognosis in HCC.
|
27644248 |
2016 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
To analyze the expression profiles of N-a-acetyltransferase 10 protein (Naa10p/ARD1) and matrix metalloproteinase 9 (MMP-9) in human breast cancer and evaluate their possible prognostic values in breast cancer patients.
|
23550278 |
2013 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
To analyze the expression profiles of N-a-acetyltransferase 10 protein (Naa10p/ARD1) and matrix metalloproteinase 9 (MMP-9) in human breast cancer and evaluate their possible prognostic values in breast cancer patients.
|
23550278 |
2013 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
ARD1 mRNA levels in HCC and corresponding non-cancerous tissues were quantified by real-time PCR.
|
23258102 |
2012 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that ARD1 expression may be as a potential target for exploring the mechanism of breast cancer metastasic to lymph nodes and hormone-responsive regulation.
|
22292636 |
2011 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that ARD1 expression may be as a potential target for exploring the mechanism of breast cancer metastasic to lymph nodes and hormone-responsive regulation.
|
22292636 |
2011 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
This review summarizes the biological functions of ARD1 in different types of cancer and provides a deep insight into the biochemical activities of ARD1 during tumor progression.
|
31813105 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the expression level of ARD1 in cancer tissues has been correlated with the progression and metastasis of the cancer and the survival of cancer patients.
|
31813105 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Among a variety of cytokines or molecules, some investigators have suggested that arrest-defective 1 (ARD1), an acetyltransferase, plays a key role in the development of malignancies.
|
30054466 |
2018 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
ARD1/NAA10 acetylation in prostate cancer.
|
30054487 |
2018 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
ARD1/NAA10 acetylation in prostate cancer.
|
30054487 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Hypoxia is known to promote hepatocellular carcinoma (HCC) invasion and metastasis and nuclear inhibitor of protein phosphatase 1 (NIPP1) overexpression contributes to the malignant phenotype in HCC.
|
27644248 |
2016 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Finally, we demonstrate that the overexpression of NIPP1 also hampered colony formation and tumor growth in xenograft assays in a PP1-dependent manner.
|
26542020 |
2015 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
With the tumor marker positive rate [32.0% (62/225) for SNCG; 76.9% (173/225) for combined SNCG/Hiwi/PRL-3/ARD1] and the detecting accuracy [61.9% (252/407) for SNCG; 82.6% (336/407) for combined SNCG/Hiwi/PRL-3/ARD1] increasing, incremental value of combined SNCG/Hiwi/PRL-3/ARD1 (P < 0.001; hazard ratios (HR), 3.2) to poor outcome was found.
|
22261620 |
2012 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Depletion of ARD1 by shRNA suppressed PCa cell proliferation, anchorage-independent growth, and xenograft tumor formation in SCID mice, suggesting that AR-dependent ARD1 expression is biologically germane.
|
22315407 |
2012 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Depletion of ARD1 by shRNA suppressed PCa cell proliferation, anchorage-independent growth, and xenograft tumor formation in SCID mice, suggesting that AR-dependent ARD1 expression is biologically germane.
|
22315407 |
2012 |