Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease BEFREE We uncovered remarkable sex differences in gene expression, including elevated expression of the EP3 receptor in females-which we leverage to illustrate the behavioral and pharmacologic relevance of these findings-and of Slc6a15 and Lin28b, both major depressive disorder (MDD)-associated genes. 29791834 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease BEFREE Collectively, our data demonstrate that reduced Slc6a15 in NAc occurs in MDD individuals and that Slc6a15 reduction in NAc D2-neurons underlies stress susceptibility.<b>SIGNIFICANCE STATEMENT</b> Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. 28576941 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 GeneticVariation disease BEFREE In the present study, we investigated the effect of the SLC6A15 gene polymorphism, rs1545843, on resting-state brain function in MDD with the imaging genomic technology and the regional homogeneity (ReHo) method. 28915082 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease BEFREE Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder. 27723767 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease PSYGENET Convergent data from human studies, animal models and pharmacological investigations suggest a possible role of SLC6A15 in major depressive disorder. 23874702 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease BEFREE Convergent data from human studies, animal models and pharmacological investigations suggest a possible role of SLC6A15 in major depressive disorder. 23874702 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 GeneticVariation disease BEFREE Thus, decreased SLC6A15 expression, due to genetic or environmental factors, might alter neuronal circuits related to the susceptibility for MD. 21521612 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.360 Biomarker disease PSYGENET Thus, decreased SLC6A15 expression, due to genetic or environmental factors, might alter neuronal circuits related to the susceptibility for MD. 21521612 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 GeneticVariation disease BEFREE A Combined Study of SLC6A15 Gene Polymorphism and the Resting-State Functional Magnetic Resonance Imaging in First-Episode Drug-Naive Major Depressive Disorder. 28915082 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 Biomarker disease BEFREE Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder. 27723767 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 Biomarker disease PSYGENET Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression. 22475622 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 Biomarker disease BEFREE Convergent data from human studies, animal models and pharmacological investigations suggest a possible role of SLC6A15 in major depressive disorder. 23874702 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 Biomarker disease PSYGENET Convergent data from human studies, animal models and pharmacological investigations suggest a possible role of SLC6A15 in major depressive disorder. 23874702 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 Biomarker disease BEFREE Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression. 22475622 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 Biomarker disease PSYGENET Thus, decreased SLC6A15 expression, due to genetic or environmental factors, might alter neuronal circuits related to the susceptibility for MD. 21521612 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.350 GeneticVariation disease BEFREE Thus, decreased SLC6A15 expression, due to genetic or environmental factors, might alter neuronal circuits related to the susceptibility for MD. 21521612 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.030 Biomarker disease BEFREE Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes. 31344373 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.030 Biomarker disease BEFREE Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes. 31344373 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.030 Biomarker phenotype BEFREE Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes. 31344373 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.030 Biomarker disease BEFREE However, no study examined Slc6a15 in the ventral striatum [nucleus accumbens (NAc)] in depression. 28576941 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.030 Biomarker disease BEFREE However, no study examined Slc6a15 in the ventral striatum [nucleus accumbens (NAc)] in depression. 28576941 2017
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.030 Biomarker phenotype BEFREE However, no study examined Slc6a15 in the ventral striatum [nucleus accumbens (NAc)] in depression. 28576941 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.030 GeneticVariation disease BEFREE Recently, a variant (rs1545843) affecting transcription of the human SLC6A15 gene has been associated with depression in a genome-wide association study. 22475622 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.030 GeneticVariation disease BEFREE Recently, a variant (rs1545843) affecting transcription of the human SLC6A15 gene has been associated with depression in a genome-wide association study. 22475622 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.030 GeneticVariation phenotype BEFREE Recently, a variant (rs1545843) affecting transcription of the human SLC6A15 gene has been associated with depression in a genome-wide association study. 22475622 2013