Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019202
Disease: Hepatolenticular Degeneration
Hepatolenticular Degeneration 		0.300 Biomarker disease CTD_human The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease. 23519153 2013
CUI: C1527352
Disease: Hepatic Form of Wilson Disease
Hepatic Form of Wilson Disease 		0.300 Biomarker disease CTD_human The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease. 23519153 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.220 AlteredExpression disease BEFREE The expression of Adcy2, Ppp3cb, and Ptk2b genes changed in both age groups; therefore, the study of gene expression profiles between juvenile and adult rats may help to understand the molecular mechanisms of schizophrenia. 29214423 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.220 Biomarker disease RGD The expression of Adcy2, Ppp3cb, and Ptk2b genes changed in both age groups; therefore, the study of gene expression profiles between juvenile and adult rats may help to understand the molecular mechanisms of schizophrenia. 29214423 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.220 Biomarker disease BEFREE Genetic analysis showed significant allelic associations of SNPs in PRKAR1A with SZ and of PPP3CB and PRKAR1A with BP. 26899345 2016
CUI: C0162770
Disease: Right Ventricular Hypertrophy
Right Ventricular Hypertrophy 		0.200 Biomarker disease RGD L-type calcium channel blocker suppresses calcineurin signal pathway and development of right ventricular hypertrophy. 16496058 2005
CUI: C0344529
Disease: Cornea plana
Cornea plana 		0.040 GeneticVariation disease BEFREE Cornea plana congenita occurs in a mild autosomal dominant (CNA1) and a more severe autosomal recessive (CNA2) form. 8723718 1996
CUI: C0344529
Disease: Cornea plana
Cornea plana 		0.040 GeneticVariation disease BEFREE Cornea plana congenita is believed to occur in a mild autosomal dominant (CNA1) and a more severe autosomal recessive (CNA2) form. 8929947 1996
CUI: C0344529
Disease: Cornea plana
Cornea plana 		0.040 GeneticVariation disease BEFREE Linkage disequilibrium mapping of the cornea plana congenita gene CNA2. 8825624 1995
CUI: C0344529
Disease: Cornea plana
Cornea plana 		0.040 GeneticVariation disease BEFREE We report the mapping of the locus for autosomal recessive cornea plana congenita (CNA2; MIM 217300) by linkage analysis to the approximately 10-cM interval between markers D12S82 and D12S327. 7601455 1995
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE Besides, in vitro and in vivo experiments indicated that the loss of PPP3CB suppressed the tumor growth. 30641937 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 AlteredExpression group BEFREE Our data indicate that elevated expression of PPP3CB and the expression of its constitutively active mutant contribute to the aggressive behavior of NB tumors and therefore suggest that inhibition of calcineurin activity might have therapeutic potential for high-risk NB. 30457174 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 AlteredExpression disease BEFREE Our data indicate that elevated expression of PPP3CB and the expression of its constitutively active mutant contribute to the aggressive behavior of NB tumors and therefore suggest that inhibition of calcineurin activity might have therapeutic potential for high-risk NB. 30457174 2019
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 AlteredExpression disease BEFREE Our data indicate that elevated expression of PPP3CB and the expression of its constitutively active mutant contribute to the aggressive behavior of NB tumors and therefore suggest that inhibition of calcineurin activity might have therapeutic potential for high-risk NB. 30457174 2019
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 AlteredExpression disease BEFREE Our data indicate that elevated expression of PPP3CB and the expression of its constitutively active mutant contribute to the aggressive behavior of NB tumors and therefore suggest that inhibition of calcineurin activity might have therapeutic potential for high-risk NB. 30457174 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.010 Biomarker disease BEFREE Genetic analysis showed significant allelic associations of SNPs in PRKAR1A with SZ and of PPP3CB and PRKAR1A with BP. 26899345 2016
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.010 Biomarker disease BEFREE Calcineurin Aβ-deficient mice were protected against induction of pancreatic inflammation by iohexol. 25980752 2015
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.010 AlteredExpression phenotype LHGDN Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes. 15557343 2005
CUI: C0003507
Disease: Aortic Valve Stenosis
Aortic Valve Stenosis 		0.010 AlteredExpression disease BEFREE A strong inverse correlation exists between ER-beta and calcineurin A-beta mRNA in patients with aortic valve stenosis (r=-0.83, P=0.002) but not between ER-alpha or -beta and BNP mRNA. 15533858 2004