|
Platelet Component Distribution Width Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Thyroid stimulating hormone measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
19197348 |
2009 |
|
Triglycerides measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
|
19197348 |
2009 |
|
leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
High EDAG-1 expression is also found in human thyroid cancer cells and peripheral blood of patients with leukemia, but its functional significance was unclear.
|
26934676 |
2016 |
|
leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
An FLT3-ITD-associated gene-expression signature revealed overexpression of FLT3, homeobox genes (MEIS1, PBX3, HOXB3), and immunotherapeutic tar-gets (WT1, CD33) and underexpression of leukemia-associated (MLLT3, TAL1) and erythropoiesis-associated (GATA3, EPOR, ANK1, HEMGN) genes.
|
20656931 |
2010 |
|
leukemia
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
This study suggests that the Hemgn promoter contains critical regulatory elements for its transcription in hematopoietic tissues and Hemgn is a direct target of GATA1 in leukemia cells.
|
16437149 |
2006 |
|
leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
We also identified a human homologue of Hemogen, named EDAG, which was mapped to chromosome 9q22, a leukemia breakpoint.
|
11404085 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We identified 5321 patients with T2DM in the SOReg and 5321 matched controls in the NDR, aged 18-65 years, with BMI >27.5 kg/m² and followed for up to 9 years.
|
30782717 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods:</b> We recruited 21 type 2 diabetes mellitus (T2DM) inpatients of Chinese Han ancestry, consisting of 10 non-proliferative DR patients (DR group) and 11 non-DR T2DM patients (NDR group).
|
31275351 |
2019 |
|
Diabetic Retinopathy
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Five miRNAs were DE between DR and NDR groups (<i>p</i>-Value ≤ 0.01, LFC ≥ 2 or LFC ≤-2).
|
31275351 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
The duration of T2DM and systolic blood pressure were significantly increased in the DR group compared with the NDR group.
|
27033231 |
2016 |
|
Diabetic Retinopathy
|
0.030 |
Biomarker
|
disease |
BEFREE |
The duration of T2DM and systolic blood pressure were significantly increased in the DR group compared with the NDR group.
|
27033231 |
2016 |
|
Childhood Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
High EDAG-1 expression is also found in human thyroid cancer cells and peripheral blood of patients with leukemia, but its functional significance was unclear.
|
26934676 |
2016 |
|
Diabetic Retinopathy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A total of 204 T2DM patients were subdivided into groups without diabetic retinopathy (NDR, n=110) and those with DR (n=94).
|
25899017 |
2015 |
|
Childhood Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
An FLT3-ITD-associated gene-expression signature revealed overexpression of FLT3, homeobox genes (MEIS1, PBX3, HOXB3), and immunotherapeutic tar-gets (WT1, CD33) and underexpression of leukemia-associated (MLLT3, TAL1) and erythropoiesis-associated (GATA3, EPOR, ANK1, HEMGN) genes.
|
20656931 |
2010 |
|
Childhood Leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
We also identified a human homologue of Hemogen, named EDAG, which was mapped to chromosome 9q22, a leukemia breakpoint.
|
11404085 |
2001 |
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
0.020 |
Biomarker
|
disease |
BEFREE |
The distinct metabolites between PDR and NDR groups were significantly enriched in 9 KEGG pathways (<i>P</i> < 0.05, impact > 0.1), namely, alanine, aspartate and glutamate metabolism, caffeine metabolism, beta-alanine metabolism, purine metabolism, cysteine and methionine metabolism, sulfur metabolism, sphingosine metabolism, and arginine and proline metabolism.
|
31160916 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Hemogen is a vertebrate transcription factor that performs important functions in erythropoiesis and testicular development and may contribute to neoplasia.
|
30097520 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We found that overexpression of EDAG-1 promoted the proliferation, invasion, and adhesion of human thyroid cancer cells, whereas silencing of EDAG-1 reversed all these changes and reduced the tumorigenesis risk of nude mice.
|
26934676 |
2016 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Moreover, knockdown of EDAG-1 suppressed tumorigenesis of thyroid carcinoma in vivo.
|
27261581 |
2016 |
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
0.020 |
Biomarker
|
disease |
BEFREE |
The PD-1 mRNA expression markedly decreased, while the frequency of PD-1(+) cells increased in the PDR group compared with the DM-NDR and control groups.
|
26321864 |
2015 |
|
Acute Erythroblastic Leukemia
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells.
|
17671716 |
2007 |
|
Acute Erythroblastic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells.
|
14730214 |
2004 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Taken together, these data are consistent with Hemogen and EDAG playing an important role in hematopoietic development and neoplasms.
|
11404085 |
2001 |
|
Retinal Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Discrimination between nondiabetic control (NC; <i>N</i> = 16) and diabetic without clinical retinopathy (NDR; <i>N</i> = 17) subjects was performed using ordinary least squares regression and Fisher's linear discriminant analysis.
|
31341653 |
2019 |