Multiple Myeloma
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
These findings implicate IRF4-mediated CDCA7L expression in MM biology and indicate how germline variation might confer susceptibility to MM.
|
27882933 |
2016 |
Multiple Myeloma
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
|
23955597 |
2013 |
Multiple Myeloma
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
|
22120009 |
2011 |
Viral Load result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
HIV-1, RESISTANCE TO
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
AIDS, PROGRESSION TO
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
Ciliary Motility Disorders
|
0.100 |
GeneticVariation
|
group |
CLINVAR |
|
|
|
Ciliary Motility Disorders
|
0.100 |
CausalMutation
|
group |
CLINVAR |
|
|
|
CILIARY DYSKINESIA, PRIMARY, 7 (disorder)
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that CDCA7L was highly expressed in human GBM tissues, and a high expression of CDCA7L was associated with a poor prognosis of glioma patients through the TCGA database.
|
31173217 |
2019 |
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that CDCA7L expression was up-regulated in different glioma types, including glioblastoma, oligodendroglioma, diffuse astrocytoma and anaplastic astrocytoma.
|
30389317 |
2019 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Moreover, the current retrospective cohort study indicated that high CDCA7L expression was associated with tumor size, WHO grade, adjuvant therapy and recurrence, as well as the poor overall survival (OS) and recurrence-free survival (RFS) in glioma patients.
|
30389317 |
2019 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In an in vivo model, subcutaneous transplantation of the tumor in nude mice showed that overexpression of CDCA7L can accelerate the tumor growth rate.
|
24141559 |
2013 |
Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Reporter gene and/or gel shift assays confirmed direct repression of Tsp-1 transcription by Myc and also identified JPO2, a Myc interactor associated with metastatic medulloblastoma, as a cofactor in Myc-mediated Tsp-1 repression.
|
20876797 |
2010 |
Childhood Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Reporter gene and/or gel shift assays confirmed direct repression of Tsp-1 transcription by Myc and also identified JPO2, a Myc interactor associated with metastatic medulloblastoma, as a cofactor in Myc-mediated Tsp-1 repression.
|
20876797 |
2010 |
Adult Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Reporter gene and/or gel shift assays confirmed direct repression of Tsp-1 transcription by Myc and also identified JPO2, a Myc interactor associated with metastatic medulloblastoma, as a cofactor in Myc-mediated Tsp-1 repression.
|
20876797 |
2010 |
Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Significantly, JPO2 expression induces colony formation in UW228, a medulloblastoma cell line, whereas RNAi-mediated JPO2 knockdown impairs colony formation in UW228, and in Myc-transformed UW228 cells.
|
15994933 |
2005 |
Childhood Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Significantly, JPO2 expression induces colony formation in UW228, a medulloblastoma cell line, whereas RNAi-mediated JPO2 knockdown impairs colony formation in UW228, and in Myc-transformed UW228 cells.
|
15994933 |
2005 |
Adult Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Significantly, JPO2 expression induces colony formation in UW228, a medulloblastoma cell line, whereas RNAi-mediated JPO2 knockdown impairs colony formation in UW228, and in Myc-transformed UW228 cells.
|
15994933 |
2005 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that CDCA7L was highly expressed in human GBM tissues, and a high expression of CDCA7L was associated with a poor prognosis of glioma patients through the TCGA database.
|
31173217 |
2019 |
Multiple Endocrine Neoplasia Type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a CpG island methylator phenotype analysis, 3 genes were identified and confirmed to have downregulated gene expression: secreted frizzle-related protein 5 (SFRP5) in sporadic NFPanNETs and cell division cycle-associated 7-like (CDCA7L) and RNA binding motif 47 (RBM47) in MEN1-related NFPanNETs.
|
30620390 |
2019 |
Adult Anaplastic Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that CDCA7L expression was up-regulated in different glioma types, including glioblastoma, oligodendroglioma, diffuse astrocytoma and anaplastic astrocytoma.
|
30389317 |
2019 |