Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No significant association was found between SSc-specific autoantibodies (anti-centromere, anti-Scl-70, anti-RNA polymerase III and anti-RNP) status and the risk of depression.
|
30268959 |
2019 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then examined anti-RNPC-3-positive cases and negative SSc controls from the University of Pittsburgh and the University of Pittsburgh Medical Center (UPMC) scleroderma cohort to confirm our findings and to examine whether specific GI features were associated with anti-RNPC-3 antibodies.
|
30242973 |
2019 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antinuclear antibodies, anti-centromere antibodies, antiphospholipid antibodies, anti-U3 RNP antibodies and anti-Th/To antibodies would appear to show a particularly important prevalence in scleroderma patients with pulmonary hypertension, appearing in about 8/10 (antinuclear), 1/ 2 (anti-centromere, anti-phospholipid), and 1/4 (anti-U3RNP, anti-Th/To) of patients.
|
30316987 |
2018 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with anti-RNPC-3 had a short cancer-scleroderma interval (median 0.9 years).
|
28217959 |
2017 |
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified a specificity for the minor spliceosome complex containing RNA Binding Region (RNP1, RNA recognition motif) Containing 3 (RNPC3) that is found in patients with scleroderma without known specificities and is absent in unrelated autoimmune diseases.
|
27821747 |
2016 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As expected, antitopoisomerase I antibody (Ab, n=64), anti-RNA polymerases (RNAP) Ab (n=12) and anti-U3 RNP Ab (n=5) were associated with diffuse cutaneous SSc, whereas anticentromere Ab (ACA, n=75), anti-Th/To Ab (n=7) and anti-U1 RNP Ab (n=10) were frequently detected in patients with limited cutaneous SSc.
|
18205876 |
2008 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Japanese scleroderma, the +49A allele of CTLA-4 increased in the presence of SSc with the anti-RNP antibody.
|
12508774 |
2003 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-Scl-70 antibodies were found in 31/84 (37%) and anti-RNP antibodies in 5/84 (6%) patients with SSc.
|
11454648 |
2001 |
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies of HLA-DR and DQ alleles in systemic sclerosis patients with autoantibodies to RNA polymerases and U3-RNP (fibrillarin).
|
10813287 |
2000 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Twenty-four sera had autoantibodies to defined nucleolar antigens by IP (seven Pm-Scl, ten RNA polymerase (pol) I, four U3 RNP, three Th RNP), and all were from patients with SSc (38.7%).
|
9058652 |
1997 |
Systemic Scleroderma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human scleroderma antiserum specific to nucleolar U3 RNP can enrich snR17 from sonicated yeast nuclear extracts.
|
3308452 |
1987 |