|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In the current study BKS-db/db mice were treated with the mitochondrial uncoupler, niclosamide ethanolamine (NEN), to determine the effects of mitochondrial uncoupling therapy on T2D, and the pathogenesis of DPN, DKD and DR.
|
30696927 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
|
30974944 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
Methods- Adult, male BKS.Cg-m+/+Lepr<sup>db</sup>/J (T2DM) mice were subjected to photothrombotic stroke model.
|
31394992 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
The inhibition of hsa-miR-483-3p in human T2D M2MΦs transplanted to athymic nude mice (NMRI-<i>Foxn1<sup>ν</sup>/Foxn1<sup>ν</sup></i> ) or systemic inhibition of mmu-miR-483* in B6.BKS(D)-<i>Lepr<sup>db</sup></i> /J diabetic mice rescued diabetes-associated impairment of reendothelialization in the murine carotid-injury model.
|
30257976 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In view of this, we used a murine model of type 2 diabetes (T2D), BKS-Lepr<sup>db</sup> , to determine whether RAPA treatment can mitigate the development of T2D-induced cardiomyopathy in adult mice.
|
29377150 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
In this study we examined whether inhibition of EGFR activation would affect the development of DN in a mouse model of accelerated type 2 diabetes (BKS <i>db/db</i> with endothelial nitric oxide knockout [eNOS<sup>-/-</sup><i>db/db</i>]). eNOS<sup>-/-</sup><i>db/db</i> mice received vehicle or erlotinib, an inhibitor of EGFR tyrosine kinase activity, beginning at 8 weeks of age and were sacrificed at 20 weeks of age.
|
29959129 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
Using male mice BKS.Cg-m+/+Leprdb/J (db/db) we investigated if treatment with cobalt protoporphyrin IX (CoPP), an HO-1 inductor, inhibited mechanical allodynia, hyperglycemia and obesity associated to type 2 diabetes.
|
29143802 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.080 |
Biomarker
|
disease |
BEFREE |
We assessed T2DM B6.BKS(D)-Leprdb/J (db/db) mice fed for six months on a normal diet containing three zinc levels (deficient, adequate, and supplemented), to explore the role of zinc in DCM development and progression.
|
28272348 |
2017 |