Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene silencing study revealed that Med promotes the development of brown- and beige-adipocyte characteristics in C3H10T1/2 mesenchymal stem cells through activation of the AMPK pathway, and our data allow us to propose Med as a candidate for therapeutics against obesity or related metabolic disorders.© 2017 BioFactors, 44(2):168-179, 2018.
|
29064586 |
2018 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impaired AMPK is associated with a wide spectrum of clinical and pathological conditions, ranging from obesity, altered responses to exercise or metabolic syndrome, to inflammation, disturbed mitochondrial biogenesis and defective response to energy stress.
|
25779083 |
2015 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resveratrol and Metformin Recover Prefrontal Cortex AMPK Activation in Diet-Induced Obese Mice but Reduce BDNF and Synaptophysin Protein Content.
|
31450493 |
2019 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice.
|
28264489 |
2017 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation.
|
31443565 |
2019 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, an α-MG supplement up-regulated hepatic AMPK, SirT1, and PPARγ levels compared with the high-fat diet states, suggesting that α-MG regulates hepatic steatosis and obesity through the SirT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice.
|
26368128 |
2015 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we determined the effect of the oral administration of the extract of <i>D. morbifera</i> on obesity and hepatic steatosis in high-fat diet (HFD)-induced obese mice.This study proved that <i>D. morbifera</i> containing HOD, the active substance, can show preventive or therapeutic efficacy on obesity and hepatic steatosis through the targeting LKB1/AMPK axis.
|
29875667 |
2018 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
As suggested by the molecular docking study, such bioactivity of alisol A may result from its selective binding to the catalytic region of AMPK.Therefore, we believe that Alisol A could serve as a promising agent for treatment of obesity and its related metabolic diseases.
|
31144451 |
2019 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice.
|
30235452 |
2018 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aims of the current study were to identify the beneficial effects of crocin on obesity, adipocyte differentiation, and lipolysis and to evaluate the possible role of AMPK.
|
30674760 |
2018 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that zerumbone ameliorated diet-induced obesity and inhibited adipogenesis, and that the underlying mechanisms involved AMPK and the microRNA-146b/SIRT1 pathway.
|
28445161 |
2017 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice.
|
30524290 |
2018 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
AMPK links inflammation, metabolism and T2D, with roles to play in all and is influenced negatively by obesity.
|
27128935 |
2016 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrate that vitamin D treatments decreased insulin resistance, reduced leptin, and increased adiponectin signaling and also regulated the LKB1/AMPK pathway contributing to an overall decrease in local estrogen synthesis in the obese mice.
|
26817629 |
2016 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
EPS improved insulin signal transduction in myotubes from lean but not severely obese subjects and increased AMP accumulation and AMPK Thr<sup>172</sup> phosphorylation, but to a lesser degree in myotubes from the severely obese.
|
30414190 |
2019 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In humans, AMPK regulates lipid and glucose metabolism and has been implicated in such metabolic disorders as diabetes and obesity and in cardiac abnormalities.
|
12847291 |
2003 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation, and cancer.
|
28622524 |
2017 |
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, our findings point to hypothalamic AMPK in specific neuronal populations as a potential druggable target for the treatment of obesity and associated metabolic disorders.
|
30104247 |
2018 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro.
|
29141998 |
2018 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
|
20444420 |
2010 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that metformin improves low-grade inflammation in obesity and modulates macrophage polarization to an anti-inflammatory, M2 phenotype partly via the activation of AMPK.
|
28935544 |
2018 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity in WT mice fed a HFD associated with elevated serum IL-6 levels, fatty liver, upregulation of carnitine palmitoyltransferase 1 (CPT1) and signal transducer and activator of transcription-3 (STAT3), increased AMP kinase phosphorylation (p-AMPK), and downregulation of the hepatic lipogenic enzymes fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1).
|
26035386 |
2015 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Indicative of a lipotoxic environment, increased placental lipid and CIDEA protein were associated with decreased AMPK and increased activation of NF-κB (p65) in placenta from obese women.
|
24484739 |
2014 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These novel findings suggest that dietary MUFA can attenuate IL-1β-mediated insulin resistance and adipose dysfunction despite obesity via the preservation of AMPK activity.
|
25626736 |
2015 |
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This increased cAMP activated AMPK, enhanced oxidative decomposition of lipids, and inhibited de novo synthesis of fatty acids, inhibiting the development and progression of obesity and type 2 diabetes.
|
28811612 |
2017 |