Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This regulatory connection between NRF2 and AMPK may have an important role in understanding how autophagy is regulated in chronic human morbidities characterized by oxidative stress, such as neurodegenerative diseases, certain cancer types, and in metabolic diseases.-Kosztelnik, M., Kurucz, A., Papp, D., Jones, E., Sigmond, T., Barna, J., Traka, M. H., Lorincz, T., Szarka, A., Banhegyi, G., Vellai, T., Korcsmaros, T., Kapuy, O. Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress.
|
30277819 |
2019 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggested that AMPK activation is a potential therapy to prevent some of the metabolic disorders attributable to air pollution exposure.
|
31071567 |
2019 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduced spontaneous contractions, AMPK activation, cell apoptosis, and energy metabolism disorders were observed in gastric smooth muscle tissues of a diabetic rat, and AMPK activation was associated with an increased ratio of ADP/ATP, AMP/ATP, LKB1 activity, and CaMMKβ expression.
|
30968342 |
2019 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK/ACC/SREBP-1c pathway.
|
31144451 |
2019 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The Potential Synergistic Modulation of AMPK by <i>Lippia citriodora</i> Compounds as a Target in Metabolic Disorders.
|
31817196 |
2019 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, our findings point to hypothalamic AMPK in specific neuronal populations as a potential druggable target for the treatment of obesity and associated metabolic disorders.
|
30104247 |
2018 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
AMPK is considered as a potential high value target for metabolic disorders.
|
29942003 |
2018 |
Metabolic Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The metabolic disorders in the liver and skeletal muscle were accompanied by the decrease in AMPK phosphorylation and activation of Akt.
|
29738801 |
2018 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Therapeutic activators of the AMP-Activated Protein Kinase (AMPK) have been proposed as a treatment for metabolic diseases; we show that the AMPK β1-biased activator PF-06409577 is capable of lowering hepatic and systemic lipid and cholesterol levels in both rodent and monkey preclinical models.
|
29673898 |
2018 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene silencing study revealed that Med promotes the development of brown- and beige-adipocyte characteristics in C3H10T1/2 mesenchymal stem cells through activation of the AMPK pathway, and our data allow us to propose Med as a candidate for therapeutics against obesity or related metabolic disorders.© 2017 BioFactors, 44(2):168-179, 2018.
|
29064586 |
2018 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation, and cancer.
|
28622524 |
2017 |
Metabolic Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, insulin-independent (heterologous) kinases can phosphorylate IRS1/2 under basal conditions (AMPK, GSK3) or in response to sympathetic activation and lipid/inflammatory mediators, which are present at elevated levels in metabolic disease (GRK2, novel and conventional PKCs, JNK, IKKβ, mPLK).
|
22869320 |
2012 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We provide evidence that the adiponectin-AMPK pathway is the main mediator of the improvement of these metabolic disorders.
|
22016761 |
2011 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabolic disorders in type 1 and type 2 diabetes.
|
21459323 |
2011 |
Metabolic Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In humans, AMPK regulates lipid and glucose metabolism and has been implicated in such metabolic disorders as diabetes and obesity and in cardiac abnormalities.
|
12847291 |
2003 |