|
Ceroid lipofuscinosis, neuronal 1, infantile
|
0.300 |
Biomarker
|
disease |
CTD_human |
Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol.
|
21224254 |
2011 |
|
Colorectal Carcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Kidney Failure, Chronic
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Mfn-1 expression and phospho-Drp1(S637)/Drp1 ratio were inhibited in the ESRD group, implicating dysfunctional mitochondrial dynamics.
|
31099942 |
2020 |
|
Kidney Failure, Chronic
|
0.210 |
Therapeutic
|
disease |
RGD |
Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics.
|
27801955 |
2017 |
|
Rhinitis
|
0.200 |
Biomarker
|
disease |
RGD |
PM
|
28146064 |
2017 |
|
Migraine Disorders
|
0.200 |
Biomarker
|
group |
RGD |
Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine.
|
27984195 |
2017 |
|
Myocardial Ischemia
|
0.200 |
Therapeutic
|
disease |
RGD |
Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKβ/AMPK pathway in isoproterenol-induced myocardial ischaemia.
|
27491814 |
2017 |
|
Pulmonary Hypertension
|
0.200 |
Biomarker
|
phenotype |
RGD |
MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.
|
27422986 |
2016 |
|
Respiratory Distress Syndrome, Adult
|
0.200 |
Therapeutic
|
disease |
RGD |
Effect of Heme Oxygenase-1 on Mitofusin-1 protein in LPS-induced ALI/ARDS in rats.
|
27830717 |
2016 |
|
Status Epilepticus
|
0.200 |
Biomarker
|
disease |
RGD |
Moreover, the mitochondrial fusion-associated proteins Mfn1 and Opa1 exhibited an increase in expression at 72h after SE.
|
27045873 |
2016 |
|
Acute Lung Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats.
|
25560372 |
2015 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats.
|
26480480 |
2015 |
|
Dental Fluorosis, Acquired
|
0.200 |
Biomarker
|
disease |
RGD |
In the cortices of the brains of rats with chronic fluorosis, the level of Mfn1 protein was clearly reduced, whereas the levels of Fis1 and Drp1 were elevated.
|
23007560 |
2013 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of mitochondrial fusion protein including mitofusin-1 (Mfn1) and optic atrophy 1 (OPA1), and mitochondrial respiratory chain complex subunits, including NDUFV2, SDHA, CYC1 and COX Ⅳ, were detected via real-time polymerase chain reaction, immunohistochemistry staining and Western blot, respectively.
|
31524603 |
2020 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the mRNA and protein expression of dynamin-related protein 1 (Drp1), mitochondrial fission factor (Mff), mitofusin 1 and 2 (Mfn1 and Mfn2), optic atrophy 1 (Opa1) indicated imbalance between mitochondrial inner and outer membrane and results in mitochondrial dysfunction in broilers BF.
|
31841897 |
2020 |
|
Optic Atrophy 1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, both HIIT and MICT interventions down-regulated dynamin-related protein 1 (DRP1) and fission 1 (FIS1), whereas mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1) were up-regulated.
|
31445975 |
2019 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of mitochondrial fission-associated proteins including dynamin-related protein 1 (DRP1) is up-regulated, whereas expression of the mitochondrial fusion-associated proteins, optic atrophy 1 and mitofusin 1, is down-regulated.
|
31085166 |
2019 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mitochondrial dynamics emphasize the critical role of mitochondrial fission proteins such as mitochondrial fission 1, dynamin-related protein 1 and mitochondrial fission factor and fusion proteins including mitofusin-1, mitofusin-2 and optic atrophy 1.
|
31032918 |
2019 |
|
Optic Atrophy 1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The inner membrane fusion protein, Optic Atrophy 1 (OPA1), was significantly increased whereas levels of outer membrane fusion proteins Mitofusin-1 and -2 (Mfn1, Mfn2) were not affected in the Lv-ALR + HR group, compared with the control group.
|
31822044 |
2019 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mitochondrial fusion is primarily controlled by three GTPases, mitofusin 1 (Mfn1), Mfn2, and optic atrophy 1 (Opa1), while mitochondrial fission is primarily regulated by GTPase dynamin-related protein 1 (Drp1).
|
31551926 |
2019 |
|
Optic Atrophy 1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SD rats were exposed to Al-maltolate complex (Al(mal)<sub>3</sub>) (blank, 0, 0.41, 0.81, or 1.62 mg/kg) for 30, 60, or 90 days, and neurobehavior, mitochondrial morphology, mitochondrial function, the levels of fission proteins such as dynamin-related protein 1 (Drp1) and fission protein 1 (Fis1), and the levels of fusion proteins such as optic atrophy 1 (Opa1), mitofusin 1 (Mfn1), and mitofusin 2 (Mfn2) were explored.
|
31055771 |
2019 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, optic atrophy 1 (<i>OPA1</i>) and mitofusin 1 (<i>MFN1</i>) were upregulated while dynamin-related protein 1 (<i>DRP1</i>) was downregulated.
|
31316549 |
2019 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent advances revealed that a number of components of the fission and fusion machinery, including dynamin-related protein 1 (Drp1), mitofusin1/2 (Mfn1/2) and Optic atrophy 1 (OPA1), that have been implicated in mitochondrial shape changes are indispensible for autophagy, apoptosis and necroptosis.
|
30312515 |
2018 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperoxic PECs exhibited increased phosphorylation of Drp-1 (serine 616), decreases in Mfn1 (mitofusion protein 1), but increases in OPA-1 (optic atrophy 1).
|
29419407 |
2018 |
|
Optic Atrophy 1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that IR-783 induced dynamin-related protein 1 (Drp1) translocation from the cytosol to the mitochondria, increased the expression of mitochondrial fission proteins mitochondrial fission factor (MFF) and fission-1 (Fis1), and decreased the expression of mitochondrial fusion proteins mitofusin1 (Mfn1) and optic atrophy 1 (OPA1).
|
29993201 |
2018 |