|
Congenital Epicanthus
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hypsarrhythmia
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Cerebellar atrophy
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Cerebral ventriculomegaly
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Severe muscular hypotonia
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Narrow forehead
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Progressive microcephaly
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Short nose
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absent speech
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Infantile encephalopathy
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Sloping forehead
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Full cheeks
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Neonatal Hypotonia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Profound intellectual disabilities
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Dilated ventricles (finding)
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Retrognathia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Neoplasm Metastasis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer.
|
29456687 |
2018 |
|
Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Swiss mice were divided into six groups, according to tumor forms: 1) ascitic model, GI (Control; 0.9% saline), GII (S<sub>180</sub>asc) and GIII (S<sub>180</sub>asc/HdCL/14 days); 2) solid model, GIV (Control; 0.9% saline), GV (S<sub>180</sub>sol) and GVI (S<sub>180</sub>sol/HdCL/10 days).
|
29079220 |
2018 |
|
Neoplasm Metastasis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
GIV expression promotes metastasis and disruption of its binding to Gαi blunts the pro-metastatic behavior of cancer cells.
|
28819150 |
2017 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Real-time PCR expression profile depicts that mature form of both miRNAs is significantly overexpressed in low-grade (GII) tumor tissue samples compared to control and high-grade (GIII and GIV) tissue samples.
|
27900675 |
2017 |
|
Neoplasm Metastasis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Gα-interacting vesicle-associated protein (GIV, aka Girdin) is a guanine exchange factor (GEF) for the trimeric G protein Gαi and a bona fide metastasis-related gene that serves as a platform for amplification of tyrosine-based signals via G-protein intermediates.
|
27440794 |
2016 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In our previous studies, we firstly found Girdin protein was overexpressed in HCC tissues, and it closely correlated to tumor size, T stage, TNM stage and Edmondson-Steiner stage of HCC patients.
|
26743900 |
2016 |
|
Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Tumor 2 had an interstitial del(2)(p16p23) deletion causing the fusion of CCDC88A and ALK.
|
25795305 |
2015 |
|
Neoplasm Metastasis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Here we report the discovery that GIV is a direct target of the transcription factor signal transducer and activator of transcription-3 (STAT3), which is commonly known as a central regulator of tumor metastasis.
|
23066027 |
2012 |
|
Neoplasm Metastasis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of Girdin protein was related to histological grade and distant metastasis (P = 0.007 and 0.007, respectively).
|
22714912 |
2012 |