|
Astrocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression of miR-124-3p and miR-128-1 decreased in astrocytomas than in normal brain tissue in all grades (p < 0.05 in both cases), and this reduction was most evident in GIV (407- and 1,469-fold, respectively); however, the expression of the precursor forms pre-miR-128-1 and pre-miR-221 was higher in GIV (3.5-fold) than in GI.
|
24718706 |
2014 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that GIV-fl is a novel metastasis-related protein and an independent adverse prognosticator that may serve as a useful adjunct to traditional staging strategies in colorectal carcinoma.
|
20974669 |
2011 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Girdin protein may be a potential new early liver metastasis biomarker of colorectal cancer.
|
22714912 |
2012 |
|
Hepatitis E
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hepatitis A virus (HAV), genogroup GI, GII, and GIV norovirus (NoV), enterovirus (EV), rotavirus (RoV), hepatitis E virus (HEV), adenovirus (AdV), and bocavirus (BoV) were detected by nested (RT) PCR, real-time PCR, and sequence analysis.
|
30639406 |
2019 |
|
Hepatitis E
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sequences related to important viral pathogens, such as the hepatitis E virus, several picornaviruses from species A and B as well as human sapoviruses and GIV noroviruses were detected.
|
28646670 |
2017 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally, animal experiments were performed to demonstrate the effect of CCDC88A silencing on the radiosensitivity of hepatoma in vivo.
|
28810896 |
2017 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
APE/Ref-1 was upregulated in HCC cells consistent with the strong expression of APE/Ref-1 in HCC tissue microarray.
|
25109342 |
2014 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.
|
27440794 |
2016 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer.
|
20974669 |
2011 |
|
Rectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective registry-based population study was to investigate the association between QoL 3 years after surgery for rectal cancer and intrusive thoughts and to assess the association with the type of surgery (i.e., APE or ELAPE) in a population-based national cohort.
|
29665309 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, our finding highlights a novel aspect of STAT3/GIV pathway in the IL-17 promotes tumor angiogenesis of NSCLC.
|
26524953 |
2015 |
|
Conjunctivitis, Acute Hemorrhagic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, our isolates shared greatest homology with the GIV-C4 strains, not with the isolates that were responsible for the nationwide acute hemorrhagic conjunctivitis epidemic in China in 2007.
|
24475191 |
2014 |
|
Japanese Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Japanese encephalitis virus (JEV) is classified into 5 genotypes (GI, GII, GIII, GIV, and GV), and the GI and GIII strains are the most widely distributed in JE endemic areas.
|
30381682 |
2019 |
|
Gastroenteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this study constitutes the first report of molecular epidemiology of human Caliciviruses associated to gastroenteritis outbreaks in Argentina and the circulation of GIIb and GIV-1 strains in South-America.
|
17854042 |
2007 |
|
Graves Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These preliminary results suggest that APE/Ref-1 (codon 148) and XRCC1 (codons 194 and 399) polymorphisms are not significant risk factors for developing GD.
|
19711438 |
2009 |
|
Hepatitis A
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hepatitis A virus (HAV), genogroup GI, GII, and GIV norovirus (NoV), enterovirus (EV), rotavirus (RoV), hepatitis E virus (HEV), adenovirus (AdV), and bocavirus (BoV) were detected by nested (RT) PCR, real-time PCR, and sequence analysis.
|
30639406 |
2019 |
|
Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using an immunohistochemical method, fixed tissue from 31 newly diagnosed pediatric rhabdomyosarcomas were evaluated for expression of APE/ref1.
|
11846302 |
2001 |
|
Vitiligo
|
0.010 |
Biomarker
|
disease |
BEFREE |
The inflammatory response in vitiligo is thought to be mediated by polymorphism in genes such as FOXP3, ACE, APE, GSTP1, TLR, SOD, CTLA-4, TAP/LMP gene cluster, etc.
|
29199612 |
2017 |
|
Spina Bifida
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Elevated or decreased odds ratios (OR, adjusted for race/ethnicity) for spina bifida were found for genotypes containing at least one copy of the variant allele for XPD [751Gln, OR = 1.62; 95% confidence interval (CI) = 1.05-2.50] and APE 148 (OR = 0.58; CI = 0.37-0.90).
|
15887293 |
2005 |
|
Alveolar rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined the role of APE/ref1 in pediatric embryonal and alveolar rhabdomyosarcomas (ARMS).
|
11846302 |
2001 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also provide evidence that GIV may serve as a biomarker for progression of fibrosis after liver injury and a therapeutic target for arresting and/or reversing HSC activation during liver fibrosis.
|
25043713 |
2014 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Girdin protein: A potential metastasis predictor associated with prognosis in lung cancer.
|
29456687 |
2018 |
|
Acute gastroenteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Noroviruses are important causes of acute gastroenteritis and are classified into six genogroups with GI, GII and GIV containing human pathogens.
|
26248055 |
2015 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After analyzing survival rates, cases with highly expressed Girdin protein were shown to attain a significantly higher rate of liver metastasis and poorer postoperative, disease-specific survival than those with no or low expressed Girdin protein (P = 0.001).
|
22714912 |
2012 |
|
Intrusive thoughts
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association between operative technique and intrusive thoughts on health-related Quality of Life 3 years after APE/ELAPE for rectal cancer: results from a national Swedish cohort with comparison with normative Swedish data.
|
29665309 |
2018 |