VPS35, VPS35 retromer complex component, 55737

N. diseases: 66; N. variants: 6
Disease: Autosomal dominant late onset Parkinson disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4274355
Disease: Autosomal dominant late onset Parkinson disease
Autosomal dominant late onset Parkinson disease 		0.040 GeneticVariation disease BEFREE Interestingly, this association was disrupted by PD-associated VPS35 mutant D620N. 28383562 2017
CUI: C4274355
Disease: Autosomal dominant late onset Parkinson disease
Autosomal dominant late onset Parkinson disease 		0.040 AlteredExpression disease BEFREE To address this, we generated transgenic Drosophila that express variant forms of human VPS35 found in PD cases and the corresponding variants of the Drosophila ortholog. 26251041 2015
CUI: C4274355
Disease: Autosomal dominant late onset Parkinson disease
Autosomal dominant late onset Parkinson disease 		0.040 GeneticVariation disease BEFREE Our data indicated that the VPS35 variants are not associated with PD in the mainland Chinese population. 22673036 2012
CUI: C4274355
Disease: Autosomal dominant late onset Parkinson disease
Autosomal dominant late onset Parkinson disease 		0.040 GeneticVariation disease BEFREE VPS35 c.1858G>A was found in all affected members of the Swiss kindred and in three more families and one patient with sporadic PD, but it was not observed in 3,309 controls. 21763482 2011