|
Non-Small Cell Lung Carcinoma
|
0.550 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of lung
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Treatment with the demethylating agent 5-aza-2'-deoxycytidine restored expression of the CHFR gene in lung cancer cell lines exhibiting aberrant hypermethylation and loss of its expression.
|
11948416 |
2002 |
|
Carcinoma of lung
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Treatment with the demethylating agent 5-aza-2'-deoxycytidine restored expression of the CHFR gene in lung cancer cell lines exhibiting aberrant hypermethylation and loss of its expression.
|
11948416 |
2002 |
|
Primary malignant neoplasm of lung
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Treatment with the demethylating agent 5-aza-2'-deoxycytidine restored expression of the CHFR gene in lung cancer cell lines exhibiting aberrant hypermethylation and loss of its expression.
|
11948416 |
2002 |
|
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We report here that a significant proportion of human esophageal cancer has loss of expression of Chfr gene.
|
12376479 |
2002 |
|
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
We report here that a significant proportion of human esophageal cancer has loss of expression of Chfr gene.
|
12376479 |
2002 |
|
Esophageal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We report here that a significant proportion of human esophageal cancer has loss of expression of Chfr gene.
|
12376479 |
2002 |
|
Malignant neoplasm of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We report here that a significant proportion of human esophageal cancer has loss of expression of Chfr gene.
|
12376479 |
2002 |
|
Lung Neoplasms
|
0.020 |
PosttranslationalModification
|
group |
LHGDN |
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
|
12538348 |
2003 |
|
Malignant Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
We found CpG methylation-dependent silencing of CHFR expression in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.
|
12810945 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To address this question, we analyzed the pattern of CHFR expression in a number of human cancer cell lines and primary tumors.
|
12810945 |
2003 |
|
Primary malignant neoplasm
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
We found CpG methylation-dependent silencing of CHFR expression in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.
|
12810945 |
2003 |
|
Malignant Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Together with recent data suggesting that the chfr gene is frequently silenced in various tumors because of methylation of its promoter, these findings suggest that chfr is inactivated by multiple mechanisms in human cancer.
|
14612512 |
2003 |
|
Primary malignant neoplasm
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Together with recent data suggesting that the chfr gene is frequently silenced in various tumors because of methylation of its promoter, these findings suggest that chfr is inactivated by multiple mechanisms in human cancer.
|
14612512 |
2003 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Moreover, the aberrant methylation of CHFR appears to be a good molecular marker with which to predict the sensitivity of gastric cancers to microtubule inhibitors.
|
14695171 |
2003 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
By affecting mitotic checkpoint function, CHFR inactivation likely plays a key role in tumorigenesis in gastric cancer.
|
14695171 |
2003 |
|
Stomach Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
By affecting mitotic checkpoint function, CHFR inactivation likely plays a key role in tumorigenesis in gastric cancer.
|
14695171 |
2003 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Thus, Chfr promoter hypermethylation is mostly cancer specific and frequently leads to chromosome instability in gastric cancer.
|
15138487 |
2004 |
|
Malignant Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Thus, Chfr promoter hypermethylation is mostly cancer specific and frequently leads to chromosome instability in gastric cancer.
|
15138487 |
2004 |
|
Carcinogenesis
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
To clarify whether Chfr promoter hypermethylation is involved in gastric carcinogenesis, we investigated the promoter methylation status of the Chfr gene in gastric cancer cell lines and primary gastric cancers.
|
15138487 |
2004 |
|
Primary malignant neoplasm
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Thus, Chfr promoter hypermethylation is mostly cancer specific and frequently leads to chromosome instability in gastric cancer.
|
15138487 |
2004 |
|
Stomach Carcinoma
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
Thus, Chfr promoter hypermethylation is mostly cancer specific and frequently leads to chromosome instability in gastric cancer.
|
15138487 |
2004 |
|
Malignant neoplasm of stomach
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that aberrant promoter methylation of the CHFR gene was observed in a significant proportion of human gastric cancers and was responsible for the inactivation of the CHFR gene in gastric cancers.
|
15201973 |
2004 |
|
Stomach Neoplasms
|
0.320 |
GeneticVariation
|
group |
BEFREE |
Eight of 12 (66.7%) gastric cancer cell lines and 19/43 (44.2%) primary gastric tumors showed CHFR methylation.
|
15201973 |
2004 |
|
Stomach Neoplasms
|
0.320 |
PosttranslationalModification
|
group |
LHGDN |
Eight of 12 (66.7%) gastric cancer cell lines and 19/43 (44.2%) primary gastric tumors showed CHFR methylation.
|
15201973 |
2004 |