|
Non-Small Cell Lung Carcinoma
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Molecular characteristics of non-small cell lung cancer with reduced CHFR expression in The Cancer Genome Atlas (TCGA) project.
|
25477232 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.550 |
PosttranslationalModification
|
disease |
BEFREE |
CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer.
|
25828518 |
2015 |
|
Non-Small Cell Lung Carcinoma
|
0.550 |
Biomarker
|
disease |
CTD_human |
A panel of seven human EGFR wild-type NSCLC cell lines was characterized for their sensitivity to sequential treatment with cisplatin and erlotinib, and the results were correlated with CHFR.
|
20705357 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
A panel of seven human EGFR wild-type NSCLC cell lines was characterized for their sensitivity to sequential treatment with cisplatin and erlotinib, and the results were correlated with CHFR.
|
20705357 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small-cell lung cancer.
|
20855974 |
2010 |
|
Non-Small Cell Lung Carcinoma
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Aurora-A and reduced expression of CHFR were found in 94 cases (59.8%) and 62 cases (39%) of NSCLC, respectively, and those were significantly correlated with tumor differentiation and size.
|
18623126 |
2008 |
|
Non-Small Cell Lung Carcinoma
|
0.550 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Cell-cycle regulation was affected by aberrant methylation of CDKN2A and CHFR in 13 GCs.
|
24510342 |
2015 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
CHFR is frequently methylated in human gastric cancer, and CHFR methylation may serve as a docetaxel-sensitive marker.
|
24748501 |
2015 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
DAPK and CHFR promoter hypermethylation may be an important help in evaluating the differentiation grade and lymph node status of gastric cancer.
|
21302620 |
2011 |
|
Malignant neoplasm of stomach
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aberrant promoter methylation of Runx3 and CHFR genes may be involved in the carcinogenesis and development of GC and may provide useful clues for the prediction of the malignant behaviors of GC.
|
20300977 |
2011 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant methylation of the CHFR gene is a frequent event in the carcinogenesis of gastric cancer.
|
20109344 |
2010 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant methylation of the CHFR gene may be involved in the carcinogenesis and development of GC, and is the predominant cause of down-regulation or loss of CHFR mRNA or protein expression.
|
18763281 |
2008 |
|
Malignant neoplasm of stomach
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The CHFR protein comprises fork head associated- (FHA) and RING-finger (RF) domain and is frequently downregulated in human colon and gastric cancers up to 50%.
|
18335050 |
2008 |
|
Malignant neoplasm of stomach
|
0.400 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Malignant neoplasm of stomach
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
DNA methylation of CHFR was found in 15 (36.6%) out of the 41 GC samples and the levels of CHFR mRNA were associated with the methylation status of CHFR (p = 0.034).
|
16475678 |
2006 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant methylation of the CHFR gene was frequently shown in esophageal and gastric cancers.
|
16827108 |
2006 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Thus, Chfr promoter hypermethylation is mostly cancer specific and frequently leads to chromosome instability in gastric cancer.
|
15138487 |
2004 |
|
Malignant neoplasm of stomach
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that aberrant promoter methylation of the CHFR gene was observed in a significant proportion of human gastric cancers and was responsible for the inactivation of the CHFR gene in gastric cancers.
|
15201973 |
2004 |
|
Malignant neoplasm of stomach
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Moreover, the aberrant methylation of CHFR appears to be a good molecular marker with which to predict the sensitivity of gastric cancers to microtubule inhibitors.
|
14695171 |
2003 |
|
Endometrial Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Our data indicate that RNA interference targeting CHFR can sensitize endometrial cancer cells to taxol and CHFR may be a promising molecular target to enhance the therapeutic effect of taxol for endometrial cancer.
|
22469813 |
2012 |
|
Endometrial Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Here, we studied the correlations between the checkpoint with forkhead-associated and ring finger (CHFR) gene expression and responses to paclitaxel in endometrial cancer cells.
|
21792009 |
2011 |
|
Endometrial Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
For example, aberrant hypermethylation of the CHFR gene is correlated with cellular sensitivity to microtubule inhibitors, and this may be useful in treatment of type I endometrial cancer.
|
19787208 |
2009 |
|
Endometrial Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer.
|
17143476 |
2007 |
|
Stomach Neoplasms
|
0.320 |
PosttranslationalModification
|
group |
LHGDN |
Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma.
|
18763281 |
2008 |