DisGeNET - a database of gene-disease associations

CHFR, checkpoint with forkhead and ring finger domains, 55743

N. diseases: 56; N. variants: 5

Disease: Carcinoma, Ovarian Epithelial ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.030

Biomarker

disease

BEFREE

The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.

29367628

2018

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.030

AlteredExpression

disease

BEFREE

CHFR promoter hypermethylation and reduced CHFR mRNA expression in ovarian cancer.

19634111

2009

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.030

Biomarker

disease

BEFREE

Our results indicate that CHFR gene status cannot serve as a molecular predictor of ovarian cancer sensitivity to taxanes.

17673375

2007