Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Spinocerebellar ataxia syndrome with axonal neuropathy (SCAN1) is a debilitating neurological disease that is caused by the mutation the Tyrosyl-DNA phosphodiesterase 1 (TDP1) DNA repair enzyme.
|
31831297 |
2020 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A homozygous mutation of human tyrosyl-DNA phosphodiesterase 1 (TDP1) causes the neurodegenerative syndrome, spinocerebellar ataxia with axonal neuropathy (SCAN1).
|
31723605 |
2019 |
Ataxia, Spinocerebellar
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, UCHL3 is downregulated in spinocerebellar ataxia with axonal neuropathy (SCAN1), causing elevated levels of TDP1 ubiquitylation and faster turnover rate.
|
29898404 |
2018 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in TDP1 and APTX have been linked to Spinocerebellar ataxia with axonal neuropathy (SCAN1) and Ataxia-ocular motor apraxia 1 (AOA1), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia-ocular motor apraxia 4 (AOA4).
|
27470939 |
2017 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Spinocerebellar ataxia with axonal neuropathy (SCAN 1) is an autosomal recessive disorder caused by a specific point mutation (c.1478A>G, p.H493R) in the tyrosyl-DNA phosphodiesterase (TDP1) gene.
|
20687496 |
2010 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The H493R mutation of Tdp1 causes the neurodegenerative disorder spinocerebellar ataxia with axonal neuropathy (SCAN1).
|
17948061 |
2007 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The H493R mutation of Tdp1 causes the neurodegenerative disorder spinocerebellar ataxia with axonal neuropathy (SCAN1).
|
17948061 |
2007 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In particular, spinocerebellar ataxia with axonal neuropathy (SCAN1) is a human disease that is associated with mutation of TDP1 (tyrosyl DNA phosphodiesterase 1) protein and with a defect in repairing certain types of SSBs.
|
17045754 |
2007 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hereditary spinocerebellar ataxia with axonal neuropathy (SCAN1) is caused by an inactivating mutation (H493R) in the enzyme tyrosyl-DNA phosphodiesterase (Tdp1), which removes blocked 3'-termini at DNA strand breaks.
|
16935573 |
2006 |
Ataxia, Spinocerebellar
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Hereditary spinocerebellar ataxia with axonal neuropathy (SCAN1) is caused by an inactivating mutation (H493R) in the enzyme tyrosyl-DNA phosphodiesterase (Tdp1), which removes blocked 3'-termini at DNA strand breaks.
|
16935573 |
2006 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease that results from mutation of tyrosyl phosphodiesterase 1 (TDP1).
|
15744309 |
2005 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The inherited disorder, spinocerebellar ataxia with axonal neuropathy (SCAN1), is caused by a H493R mutation in Tdp1.
|
15920477 |
2005 |
Ataxia, Spinocerebellar
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess whether TDP1 is primarily responsible for PG removal during in vitro end joining of DNA double-strand breaks (DSBs), whole-cell extracts were prepared from lymphoblastoid cells derived either from spinocerebellar ataxia with axonal neuropathy (SCAN1) patients, who have an inactivating mutation in the active site of TDP1, or from closely matched normal controls.
|
15647511 |
2005 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy.
|
12244316 |
2002 |
Ataxia, Spinocerebellar
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy.
|
12244316 |
2002 |