PRKCA, protein kinase C alpha, 5578

N. diseases: 368; N. variants: 15
Disease: Hyperglycemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 AlteredExpression disease BEFREE AR, PKC protein levels and related signalling molecules were increased with hyperglycemia and oxidative stress. 31743046 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 AlteredExpression disease BEFREE These findings demonstrate that PKCα promotes microvillus membrane DMT1 expression and intestinal iron uptake, contributing to diabetic iron loading.-Zhao, L., Bartnikas, T., Chu, X., Klein, J., Yun, C., Srinivasan, S., He, P. Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner. 30423260 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 Biomarker disease BEFREE Our findings suggest that DIM may ameliorate hyperglycemia and diabetic nephropathy through the inhibition of PKC-α and TGF-β1 signaling. 31817632 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 AlteredExpression disease BEFREE Besides, PKC α dependent ERK signaling pathway was found activated (1.43 fold) leading to cardiac dysfunction during hyperglycemia. 29477910 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 Biomarker disease BEFREE Apn has protective effects against hyperglycemia and can effectively enhance antioxidation, promote the secretion of insulin and reduce the accumulation of glycosylated products in T2DM mice; these effects were associated with inhibition of PKC and promotion of PKA signaling. 28954262 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 Biomarker disease BEFREE Pharmacological inhibition of NADPH oxidase, PKC-a, PKC-ß or PKC-ßI via their specific inhibitors and neutralisation of O2 (•-) by a cell-permeable superoxide dismutase mimetic, MnTBAP normalised all the aforementioned increases induced by hyperglycaemia. 24936444 2014
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 Biomarker disease BEFREE In summary, we have provided a molecular model of hyperglycemia-induced nephrin endocytosis and subsequent proteinuria and highlighted PKCα and PICK1 as promising therapeutic targets for diabetic nephropathy. 21321125 2011
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 AlteredExpression disease BEFREE Hyperglycemia induced the expression of PKC-beta1 and PKC-beta2; however, only inhibition of PKC-beta1 but not PKC-beta2 led to a significant decrease of FGF-2 levels. 19279131 2009
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.090 Biomarker disease BEFREE Taken together, our data suggest that hmunc13 serves as a diacylglycerol-activated, PKC-independent signaling pathway capable of inducing apoptosis and that this pathway may contribute to the renal cell complications of hyperglycemia. 10233166 1999