PRKCI, protein kinase C iota, 5584

N. diseases: 78; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 GeneticVariation disease BEFREE We found that SNPs in the AKAP10 and PRKCI genes are significantly associated with bipolar disorder and gene expression variation. 21382426 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease BEFREE Even though the glutamatergic and HPA pathways may not be involved in BD-AUD and BD-SUD comorbidity, PRKCI deserves further investigation in BD-AUD. 26563126 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET Postmortem studies identified PKCI/HINT1 as a candidate molecule for schizophrenia and bipolar disorder. 19912621 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET We found that SNPs in the AKAP10 and PRKCI genes are significantly associated with bipolar disorder and gene expression variation. 21382426 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.300 Biomarker disease PSYGENET Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory. 22485133 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory. 22485133 2012
CUI: C0278883
Disease: Metastatic melanoma
Metastatic melanoma 		0.300 GeneticVariation disease UNIPROT
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Protein kinase C modulation of the regulation of sarcoplasmic reticular function by protein kinase A-mediated phospholamban phosphorylation in diabetic rats. 14691046 2004
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.200 Biomarker disease MGD
CUI: C0028754
Disease: Obesity
Obesity 		0.200 Biomarker disease MGD
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker disease MGD
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.130 Biomarker disease BEFREE Larger studies with multiethnic groups are warranted to confirm these findings and to explore the role of PRKCI SNPs in the etiology of PCa. 24510606 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.130 GeneticVariation disease BEFREE Our findings showed that rs546950 polymorphism of PRKCI decreased the risk of PCa in codominant (OR=0.35, 95%CI=0.19-0.64, P<0.001, CT vs CC) and dominant (OR=0.39, 95%CI=0.22-0.69, P=0.001, CT+TT vs CC) inheritance model tested. 26475383 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.130 GeneticVariation disease GWASCAT Two susceptibility loci identified for prostate cancer aggressiveness. 25939597 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.130 AlteredExpression disease BEFREE In conclusion, we found an association with prostate cancer risk for two SNPs belonging to PRKCI, a gene which is frequently overexpressed in various neoplasms, including prostate cancer. 21373201 2011
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 Biomarker disease LHGDN Regulation of glioblastoma cell invasion by PKC iota and RhoB. 18212741 2008
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 Biomarker disease BEFREE Previously, we have shown that protein kinase C iota (PKCι) depletion induces cellular senescence in glioblastoma cells in the absence of a detectable DNA damage response. 26208522 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 AlteredExpression disease BEFREE This phenomenon was not restricted to breast cancer cells, as it was also seen in glioblastoma cells in which PKCι is activated by loss of PTEN. 22120720 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 Biomarker disease BEFREE In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem-like cell (GSC) survival. 27299852 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.050 Biomarker disease BEFREE The focus of this research was to investigate the role of protein kinase C-iota (PKC-ι) in regulation of Bad, a pro-apoptotic BH3-only molecule of the Bcl-2 family in glioblastoma. 21419810 2011
CUI: C0017638
Disease: Glioma
Glioma 		0.040 Biomarker disease LHGDN Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells. 15695176 2005
CUI: C0017638
Disease: Glioma
Glioma 		0.040 Biomarker disease BEFREE Since, PKC-ι is an essential downstream mediator of the PI (3)-kinase, we hypothesize that glioma cell survival is mediated via a PI (3)-kinase/PDK1/PKC-ι/Bad pathway. 21419810 2011
CUI: C0017638
Disease: Glioma
Glioma 		0.040 Biomarker disease BEFREE Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545. 31409777 2019
CUI: C0017638
Disease: Glioma
Glioma 		0.040 AlteredExpression disease BEFREE Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma. 30204596 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.040 Biomarker disease BEFREE The PRKCI-YAP1 regulation of the tumor immunity provides a therapeutic strategy for highly lethal ovarian cancer. 28698296 2017