PRKCI, protein kinase C iota, 5584

N. diseases: 78; N. variants: 3
Disease: Cyst ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010709
Disease: Cyst
Cyst 		0.010 Biomarker disease BEFREE By manipulating PKCι function using mutant constructs, siRNA depletion or chemical inhibition, we have demonstrated that PKCι is required for polarization of parental MDCK epithelial cysts in a 3D matrix and that there is a threshold of PKCι activity above and below which, disorganized epithelial morphogenesis results. 24072773 2014