PRKCI, protein kinase C iota, 5584

N. diseases: 78; N. variants: 3
Disease: Esophageal Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.030 Biomarker group BEFREE These results suggested that PKCι positively regulated β-catenin through negatively regulated autophagy and depletion of PKCι promoted apoptosis via autophagic degradation of β-catenin in esophageal cancer cells. 23359356 2014
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.030 Biomarker group BEFREE In vivo experiments showed that PKCι suppression decreased tumor growth in esophageal cancer xenografts and lung metastases in nude mice. 21310827 2011
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.030 GeneticVariation group BEFREE To investigate further the role of PRKCI alteration in esophageal tumors, a tissue microarray containing samples from 180 ESCCs was used for immunohistochemistry analysis. 17990328 2008