PRKCI, protein kinase C iota, 5584

N. diseases: 78; N. variants: 3
Disease: Malignant neoplasm of ovary ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 Biomarker disease BEFREE Atypical protein kinase Cι (PKCι) is an oncogene in lung and ovarian cancer. 27321186 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 Biomarker disease BEFREE The PRKCI-YAP1 regulation of the tumor immunity provides a therapeutic strategy for highly lethal ovarian cancer. 28698296 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 Biomarker disease BEFREE These data demonstrate that PKCι is required for a TIC phenotype in ovarian cancer, and that auranofin is an attractive therapeutic option to target deadly ovarian TICs in ovarian cancer patients. 24174471 2013