|
Steatohepatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis.
|
30523156 |
2019 |
|
Steatohepatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mice globally lacking Them2 are resistant to diet-induced obesity and hepatic steatosis, and exhibit improved glucose homeostasis.
|
30516845 |
2019 |
|
Dyslexia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, healthy subjects bearing the KIAA0319/TTRAP/THEM2 variants previously identified as enhancing the risk of dyslexia showed a reduced left-hemispheric asymmetry of the STS.
|
22262880 |
2012 |
|
Dyslexia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We have recently identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans the TTRAP gene and portions of THEM2 and KIAA0319.
|
16600991 |
2006 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice globally lacking Them2 are resistant to diet-induced obesity and hepatic steatosis, and exhibit improved glucose homeostasis.
|
30516845 |
2019 |
|
Dyslipidemias
|
0.010 |
Biomarker
|
group |
BEFREE |
When taken together with its functions in brown adipose and muscle, these findings suggest that Them2 is a target for the management of NAFLD and dyslipidemia.
|
30516845 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
When taken together with its functions in brown adipose and muscle, these findings suggest that Them2 is a target for the management of NAFLD and dyslipidemia.
|
30516845 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, ACOT11 and ACOT13 were upregulated in clinical specimens of lung adenocarcinoma, which may contribute to increased cell proliferation through the increased availability of fatty acids.
|
28927126 |
2017 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Considering that the formation of larger lipid droplets may serve to protect against lipotoxicity in NASH, our findings suggest a pathogenic role for PC-TP that could be targeted in the management of this condition.<b>NEW & NOTEWORTHY</b> Phosphatidylcholine-transfer protein (PC-TP) is a highly specific phosphatidylcholine-binding protein that we previously showed to regulate hepatocellular nutrient metabolism through its interacting partner thioesterase superfamily member 2 (Them2).
|
28385694 |
2017 |
|
beta^0^ Thalassemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two of them (2/69, 3.0%) were found to be double heterozygotes for β(0)-thalassemia and α(0)-thalassemia.
|
24356175 |
2014 |
|
alpha^0^ Thalassemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two of them (2/69, 3.0%) were found to be double heterozygotes for β(0)-thalassemia and α(0)-thalassemia.
|
24356175 |
2014 |
|
Developmental reading disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with developmental dyslexia.
|
23954868 |
2013 |
|
Reading Disabilities
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutations of the FOXP2 gene cause a severe form of language impairment and orofacial dyspraxia, while single-nucleotide polymorphisms (SNPs) located within a KIAA0319/TTRAP/THEM2 gene cluster and affecting the KIAA0319 gene expression are associated with reading disability.
|
22262880 |
2012 |
|
Mental Disorders, Severe
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nonetheless, these severe mental disorders have been maintained at a constant relatively high prevalence in the worldwide population across a wide range of cultures and countries despite a strong negative selection against them(2).
|
21712793 |
2011 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
To conclude, the associated GGCCTT genotype in the promoter of MMP-2 gene was less frequent in patients with positive family history of psoriasis, diabetes and personal history of allergy compared with psoriatic patients without them (2/11 vs. 68/57, P = 0.007, Pcorr = 0.04; OR = 0.15, 95% CI = 0.03-0.72 for psoriatic patients with family history of psoriasis and diabetes and with allergy).
|
19360430 |
2009 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
To conclude, the associated GGCCTT genotype in the promoter of MMP-2 gene was less frequent in patients with positive family history of psoriasis, diabetes and personal history of allergy compared with psoriatic patients without them (2/11 vs. 68/57, P = 0.007, Pcorr = 0.04; OR = 0.15, 95% CI = 0.03-0.72 for psoriatic patients with family history of psoriasis and diabetes and with allergy).
|
19360430 |
2009 |
|
Psoriasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To conclude, the associated GGCCTT genotype in the promoter of MMP-2 gene was less frequent in patients with positive family history of psoriasis, diabetes and personal history of allergy compared with psoriatic patients without them (2/11 vs. 68/57, P = 0.007, Pcorr = 0.04; OR = 0.15, 95% CI = 0.03-0.72 for psoriatic patients with family history of psoriasis and diabetes and with allergy).
|
19360430 |
2009 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although these data do not support a hypothesis that there is a role for these two HHVs in the pathogenesis of MS, nevertheless it may be suggested that (1) the two viruses possess strong neurotropism and the central nervous system seems to be a reservoir for them (2) HHV-6 infection is probably not transmitted maternally, but is acquired later in infancy.
|
9266465 |
1997 |
|
Infection by human herpesvirus 6
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although these data do not support a hypothesis that there is a role for these two HHVs in the pathogenesis of MS, nevertheless it may be suggested that (1) the two viruses possess strong neurotropism and the central nervous system seems to be a reservoir for them (2) HHV-6 infection is probably not transmitted maternally, but is acquired later in infancy.
|
9266465 |
1997 |