PRKD1, protein kinase D1, 5587

N. diseases: 171; N. variants: 19
Disease: Minor Salivary Gland Adenocarcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1334768
Disease: Minor Salivary Gland Adenocarcinoma
Minor Salivary Gland Adenocarcinoma 		0.010 GeneticVariation disease BEFREE Our results demonstrated that (1) PACs/CASGs are underpinned by genetic alterations affecting PRKD genes; (2) despite the associations between PAC and PRKD1 hotspot mutations and CASG and PRKD1/2/3 fusion, such distinction is not absolute; and (3) there is of a novel genotypic-phenotypic association whereby fusion-positive tumors are usually located in the base of the tongue, show papillary architecture and have a high risk of nodal metastasis. 31492931 2020