Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.330 GeneticVariation group BEFREE We investigated the possible association of the most common single nucleotide polymorphisms (SNPs) in the GABA receptor alpha4 (GABRA4), epsilon (GABRE), and theta (GABRQ) genes with the risk for migraine. 29299688 2018
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.330 Biomarker group GENOMICS_ENGLAND Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. 26350204 2015
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.330 GeneticVariation group BEFREE The AT genotype of rs3810651 of GABRQ gene was associated with an increased risk for migraine (OR: 4.07; 95% CI: 1.71-9.73, p=0.002), while the CT genotype of rs3902802 (OR: 0.41; 95% CI: 0.21-0.78, p=0.006) and GA genotype of rs2131190 of GABRA3 gene (OR: 0.53; 95% CI: 0.32-0.88, p=0.013) seem to be protective factors. 24040174 2013
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.330 Biomarker group BEFREE In this study, we have focused on the subunit GABA A receptors type epsilon (GABRE) and type theta (GABRQ) genes and their involvement in migraine. 19087248 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.310 GeneticVariation disease BEFREE Schizophrenia-related deficits in theta generation are also observed not only in MMN, but also in other auditory and visual contexts. 28666633 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.310 Biomarker disease GENOMICS_ENGLAND Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. 26350204 2015
CUI: C0018817
Disease: Atrial Septal Defects
Atrial Septal Defects
0.300 Biomarker group GENOMICS_ENGLAND Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. 26350204 2015
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders
0.300 Biomarker disease GENOMICS_ENGLAND Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. 26350204 2015
CUI: C1862389
Disease: ATRIAL SEPTAL DEFECT 1
ATRIAL SEPTAL DEFECT 1
0.300 Biomarker disease GENOMICS_ENGLAND Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. 26350204 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.020 Biomarker disease BEFREE A recent study reported that GABRQ is involved in the initiation and progression of hepatocellular carcinoma; however, the role of GABRQ in ccRCC remains unknown. 31788046 2019
CUI: C0004096
Disease: Asthma
Asthma
0.020 GeneticVariation disease BEFREE Glutathione- S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma. 11862323 2002
CUI: C0004096
Disease: Asthma
Asthma
0.020 GeneticVariation disease BEFREE Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. 10840461 2000
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.020 AlteredExpression disease BEFREE Both zeta and theta gene expression appears erythroid specific in that neither mRNA species is detected in RNA isolated from brain tissue, peripheral blood mononuclear cells, or three nonerythroid cell lines (B-lymphocyte, T-lymphocyte, and hepatoma cell lines). 2752137 1989
CUI: C0003467
Disease: Anxiety
Anxiety
0.010 Biomarker disease BEFREE Anxiety process "theta" biomarker in the stop signal task eliminated by a preceding relaxation test. 31219261 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.010 Biomarker group BEFREE Anxiety process "theta" biomarker in the stop signal task eliminated by a preceding relaxation test. 31219261 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.010 Biomarker disease BEFREE A recent study reported that GABRQ is involved in the initiation and progression of hepatocellular carcinoma; however, the role of GABRQ in ccRCC remains unknown. 31788046 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 GeneticVariation disease BEFREE Role of the renin-angiotensin-aldosterone system and the glutathione S-transferase Mu, Pi and Theta gene polymorphisms in cardiotoxicity after anthracycline chemotherapy for breast carcinoma. 23999848 2013
CUI: C0040822
Disease: Tremor
Tremor
0.010 GeneticVariation phenotype BEFREE The GABRQ-478F allele seemed to be related to improvement of tremor with ethanol use among men (odds ratio=2.32, 95% confidence interval=0.26-4.3, P=0.007, Pc=0.021). 21422964 2011
CUI: C0270736
Disease: Essential Tremor
Essential Tremor
0.010 Biomarker disease BEFREE The results of this study suggest that the single nucleotide polymorphisms studied in the GABRA4, GABRE, and GABRQ genes are not related to the risk for familial ET. 21422964 2011
Malignant neoplasm of urinary bladder
0.010 GeneticVariation disease BEFREE Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. 10840461 2000
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.010 GeneticVariation disease BEFREE Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. 10840461 2000
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.010 GeneticVariation disease BEFREE Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. 10840461 2000
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.010 GeneticVariation disease BEFREE Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. 10840461 2000
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.010 GeneticVariation disease BEFREE Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States). 9242470 1997
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.010 GeneticVariation disease BEFREE Polymorphisms in the glutathione S-transferase class mu and theta genes interact and increase susceptibility to lung cancer in minority populations (Texas, United States). 9242470 1997