|
Abnormal behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The possibility to target MAPK/ERK in developing and/or refining pharmacological approaches to treat psychiatric disorders in which fear regulation is defective has also been envisaged.
|
24080449 |
2014 |
|
Abnormal behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Pharmacological targeting of ERK reversed dendritic alterations associated with dp/+ neurons, outlining a strategy for the analysis and reversal of cellular phenotypes in CNV-related psychiatric disorders.
|
27402753 |
2016 |
|
Abnormality of earlobe
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Absent fingernail
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absent toenail
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acanthosis Nigricans
|
0.010 |
Biomarker
|
disease |
BEFREE |
The demonstration of a pathogenic role for p38 activation may lead to the development of therapeutic strategies for BSS and related conditions, such as acanthosis nigricans or craniosynostosis.
|
22585574 |
2012 |
|
Achondroplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations make ERK1 and ERK2 an attractive target for the treatment of achondroplasia and other FGFR3-related skeletal syndromes.
|
20922792 |
2011 |
|
Acoustic Neuroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activation of EGFR and FGFR may promote invasive behavior in VS through ERK and Akt signaling pathways.
|
21178801 |
2011 |
|
Acquired Immunodeficiency Syndrome
|
0.010 |
Biomarker
|
group |
BEFREE |
These observations suggest that suppression of these molecules, which are involved in the TLR4-MyD88 pathway and the downstream p38 MAPK and NF-kappaB pathways, should be beneficial to prevent development of AIDS in HIV-1-infected people.
|
20504885 |
2010 |
|
Actinic keratosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
HE-staining, Immunohistochemical, Western blot and Enzyme Linked Immunosorbent Assay were applied to examine the clinicopathologic feature of AK and the change of p38 MAPK signal pathway treated with astraglin under the condition of UVB in vitro and in vivo.
|
29298652 |
2018 |
|
Actinic keratosis
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Significance of the expression of phosphorylated-STAT3, -Akt, and -ERK1/2 in several tumors of the epidermis.
|
17686614 |
2007 |
|
Acute cerebral ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neuroprotective Effect of Sirt2-specific Inhibitor AK-7 Against Acute Cerebral Ischemia is P38 Activation-dependent in Mice.
|
29382550 |
2018 |
|
Acute Erythroblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, RNA interference (RNAi)-mediated suppression of SHIP-1 in erythroleukemia cells activates the phosphatidylinositol 3-kinase (PI 3-K) and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathways, blocks erythroid differentiation, accelerates erythropoietin-induced proliferation, and leads to PI 3-K-dependent Fli-1 up-regulation.
|
20445019 |
2010 |
|
Acute GVH disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
By using p40-deficient mice, we found that both donor- and host-derived p40 contribute to the development of aGVHD.
|
25846718 |
2015 |
|
Acute hepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we found that a mutation of alternative p38 in mice augmented the severity of acute liver inflammation.
|
31780731 |
2019 |
|
Acute HIV infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Significant reduction in transcription of IL-12 p40 was observed following acute HIV infection.
|
12202149 |
2002 |
|
Acute leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias.
|
17726105 |
2007 |
|
Acute lymphocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results provide a possible underlying molecular mechanism to explain the association between reduced MIR335 with poor clinical outcome, and suggest that approaches to re-introduce MIR335 expression or override MAPK1 activity may offer promising therapeutic strategies in the treatment of ALL.
|
23888996 |
2013 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Bcl-2/Bcl-xL/Bax and the Ras/Raf/MEK/ERK (MAPK) pathways are often deregulated in many human cancers and especially in acute lymphoblastic leukemia and acute myeloid leukemia.
|
24083449 |
2013 |
|
Acute monocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
|
29208365 |
2018 |
|
Acute myelomonocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In HL-60 human myeloblastic leukemia cells, retinoic acid is known to cause cFMS, RAF, MEK, and ERK2 dependent myeloid cell differentiation and G0 arrest associated with RB tumor suppressor protein hypophosphorylation, implicating receptor tyrosine kinase signal transduction in propelling these retinoic acid-induced cellular effects.
|
10222145 |
1999 |
|
Acute myocardial infarction
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Using acute myocardial infarction rat models, we found that a combination therapy of CaSR inhibition and embryonic stem cell (ESC) transplantation after acute myocardial infarction (AMI) leads to a dramatic reduction in the infarct size; a significant increase in the maximum rising and falling rate (+dp/dtmax and -dp/dtmax, respectively) of left ventricular pressure; a significant decrease in left ventricular end-diastolic pressure; a significant decrease in the mRNA expression level of CaSR, Bax, Bcl-2, cleaved caspase-3, cleaved caspase-9, p-ERK, p-JNK and p-P38 protein together with apoptosis indexes in the C and E groups; and a significant decrease in cTnT levels as well as LDH and CK activity.
|
28281186 |
2017 |
|
Acute myocardial infarction
|
0.050 |
Biomarker
|
disease |
BEFREE |
The results of in vivo assays demonstrated that Ginkgo biloba extract prevents AMI and suppresses inflammation‑ and apoptosis‑regulating p38 MAPK, NF‑κB and Bcl‑2 signaling pathways.
|
28713946 |
2017 |
|
Acute myocardial infarction
|
0.050 |
Biomarker
|
disease |
BEFREE |
Compared with the AMI group, BHD promoted the expression of Cav-1, VEGF, VEGFR2, and p-ERK in the infarction border zone after AMI.
|
31178960 |
2019 |
|
Acute myocardial infarction
|
0.050 |
Biomarker
|
disease |
BEFREE |
Treatment with AA significantly inhibited the phosphorylation of P47(phox) and ERK in the stimulated controls and MI neutrophils.
|
26319153 |
2015 |