MAPK1, mitogen-activated protein kinase 1, 5594

N. diseases: 1059; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.010 AlteredExpression disease BEFREE Protein expression in PBMCs of cyclooxygenase-2 (COX-2) and the activated forms of the mitogen-activated protein kinases p38 and ERK were also increased in the AN group. 31398429 2020
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia 		0.010 AlteredExpression disease BEFREE Oridonin enhances γ‑globin expression in erythroid precursors from patients with β‑thalassemia via activation of p38 MAPK signaling. 31789406 2020
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.010 Biomarker disease BEFREE MEK/ERK pathway signaling has been proven to be important in PDA. lncRNA-mRNA networks have become a vital part of molecular mechanisms in the MEK/ERK pathway. 31583713 2020
CUI: C0014078
Disease: Venezuelan equine encephalomyelitis
Venezuelan equine encephalomyelitis 		0.010 Biomarker disease BEFREE EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death. 31733451 2020
CUI: C0022354
Disease: Jaundice, Obstructive
Jaundice, Obstructive 		0.010 AlteredExpression disease BEFREE All these data demonstrated that p38 MAPK-pHsp27 mediates vascular hyporesponsiveness in rats with obstructive jaundice by modulating the expression level of pHsp27 and F-actin, and that inhibition of p38 MAPK signaling could remodel the vascular activity. 31810142 2020
CUI: C0035334
Disease: Retinitis Pigmentosa
Retinitis Pigmentosa 		0.010 Biomarker disease BEFREE The mechanism might be related to inhibit the activation of P38 pathway.<b>Conclusions:</b> This study showed the beneficial effects of DHAG, a compound possessing antioxidant properties, and provided scientific rationale to develop DHAG as a potential agent to treat RP. 31648555 2020
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.010 Biomarker group BEFREE Hyperoside markedly inhibited diffuse epidermal hyperplasia and significantly reduced the changes in phosphorylated levels of PI3K, AKT, mTOR and AMPK while reducing p38 phosphorylation as well as of tumor burden <i>in vivo</i> in DMBA/TPA induced skin tumors. 31585897 2020
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.010 Biomarker phenotype BEFREE We interrogated the well-described mechanism of MEK/ERK pathway inhibitor addiction in solid tumors and found it does not apply to ALCL. 31804622 2020
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.010 Biomarker disease BEFREE We interrogated the well-described mechanism of MEK/ERK pathway inhibitor addiction in solid tumors and found it does not apply to ALCL. 31804622 2020
CUI: C0262587
Disease: Parathyroid Adenoma
Parathyroid Adenoma 		0.010 Biomarker disease BEFREE The current study revealed that ERK pathway and associated cell cycle regulator genes are dysregulated in sporadic parathyroid adenoma. 31535356 2020
CUI: C0267937
Disease: Acute recurrent pancreatitis
Acute recurrent pancreatitis 		0.010 AlteredExpression disease BEFREE MAPK/ERK pathway activity was assessed by immunoblotting and in vivo by immunohistochemistry with a cerulein-induced RAP mouse model. 31091220 2020
CUI: C0600327
Disease: Toxic Shock Syndrome
Toxic Shock Syndrome 		0.010 Biomarker disease BEFREE Our work also strongly supported that Src, ERK and STAT signaling inhibitors could be effective therapeutic agents against diseases like toxic shock syndrome or infection by microbes resistant to antibiotics. 30660176 2020
CUI: C0940937
Disease: precancerous lesions
precancerous lesions 		0.010 Biomarker phenotype BEFREE DFMO was also found to suppress the development of esophageal precancerous lesions in an NMBA-induced rat model; IHC demonstrated p38 α, ERK1/2, and AKT/mTOR/p70S6K pathways to be downregulated in these rats. 31793679 2020
CUI: C2062441
Disease: Influenza A
Influenza A 		0.010 AlteredExpression disease BEFREE Furthermore, the expression of matrix metalloproteinase-13 was regulated by influenza A virus through activation of the p38 MAPK signal pathway. 31693113 2020
CUI: C3672440
Disease: Bile duct hyperplasia
Bile duct hyperplasia 		0.010 Biomarker disease BEFREE Taken together, after chronic exposure, MC-LR-treated mice exhibited abnormal bile duct hyperplasia and thickened bile duct morphology through activating the ERK-RSK signaling. 31677783 2020
CUI: C3714602
Disease: Staphylococcal toxic shock syndrome
Staphylococcal toxic shock syndrome 		0.010 Biomarker disease BEFREE Our work also strongly supported that Src, ERK and STAT signaling inhibitors could be effective therapeutic agents against diseases like toxic shock syndrome or infection by microbes resistant to antibiotics. 30660176 2020
CUI: C3841475
Disease: beta^+^ Thalassemia
beta^+^ Thalassemia 		0.010 AlteredExpression disease BEFREE Oridonin enhances γ‑globin expression in erythroid precursors from patients with β‑thalassemia via activation of p38 MAPK signaling. 31789406 2020
CUI: C4282128
Disease: PATENT DUCTUS ARTERIOSUS 1
PATENT DUCTUS ARTERIOSUS 1 		0.010 Biomarker disease BEFREE MEK/ERK pathway signaling has been proven to be important in PDA. lncRNA-mRNA networks have become a vital part of molecular mechanisms in the MEK/ERK pathway. 31583713 2020
CUI: C4546431
Disease: Exacerbation of allergic asthma
Exacerbation of allergic asthma 		0.010 Biomarker disease BEFREE Blocking TRPV4or p38 MAPK using HC-067047 and SB203580 respectively, effectively alleviated the exacerbation of allergic asthma induced by this simultaneous exposure to formaldehyde and high relative humidity. 31662264 2020
CUI: C0001857
Disease: AIDS related complex
AIDS related complex 		0.010 AlteredExpression disease BEFREE Taken together, our results implied that the elevated LMα4, which was possibly caused by the decreased MMP-9, increased TGF-β1 and activated p38 MAPK signaling during senescence, leading to the development of ARC. 31076560 2019
CUI: C0002448
Disease: Ameloblastoma
Ameloblastoma 		0.010 GeneticVariation disease BEFREE Adamantinoma-like Ewing sarcoma (ALES) is a rare tumor that demonstrates the EWSR1-FLI1 translocation characteristic of Ewing sarcoma despite overt epithelial differentiation including diffuse expression of cytokeratins and p40. 30285997 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.010 Biomarker disease BEFREE <b>Materials and methods:</b> Humanized mouse model with SCD defined as moderate- and non-responders to EA were intraperitoneally administered with antagonist of SP receptor NK1R (netupitant, 10 mg/kg/day, i.p.) or p38 MAPK inhibitor (SB203580, 10 mg/kg/day, i.p.) alone or in combination with EA (acupoint GB30, every 3rd day until day 12). 31447579 2019
CUI: C0003857
Disease: Congenital arteriovenous malformation
Congenital arteriovenous malformation 		0.010 Biomarker disease BEFREE Culprit gene mutations typically involve two major signaling pathways; the RAS/MAPK/ERK pathway is typically involved in fast-flow arteriovenous malformations, whereas the PI3K/AKT/mTOR pathway is typically mutated in slow-flow venous and lymphatic malformations. 30922748 2019
CUI: C0005866
Disease: Bluetongue infection
Bluetongue infection 		0.010 Biomarker disease BEFREE Novel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling Pathway. 31167915 2019
CUI: C0006277
Disease: Bronchitis
Bronchitis 		0.010 Biomarker disease BEFREE The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus. 31082732 2019