Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Phosphorylation of p38 MAPK and cytosolic phospholipase A<sub>2</sub> (cPLA<sub>2</sub>) was enhanced after incubation of platelets with T2D TGRL and thrombin (+87% and +32%, respectively, P < 0.05) compared with platelets incubated with thrombin only. 30981822 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Our data demonstrate a novel role of NOS1AP in regulating hepatic insulin sensitivity and p38 MAPK inactivation in obese mice, which makes NOS1AP a potential therapeutic target for the prevention and treatment of T2D. 31473185 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Abbreviations: AC: adenylyl cyclase; AMPK: AMP-activated protein kinase; βAR: β-adrenergic receptor; CA: catecholamine; cAMP: cyclic adenosine monophosphate; cGMP: cyclic guanosine monophosphate; DPP-4: dipeptidyl peptidase-4; ERK: extracellular signal-regulated kinase; GC: guanylyl cyclase; GH: growth hormone; GLP-1: glucagon-like peptide-1; GLUT: glucose transporter; HSL: hormone-sensitive lipase; IR: insulin receptor; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; MEK: MAPK/ERK kinase; MG: maltase-glucoamylase; NP: natriuretic peptide; NPR: natriuretic peptide receptor; mTORC2: mechanistic target of rapamycin complex-2; PC: proanthocyanidin; PI3K: phosphoinositide 3-kinase; PKA: cAMP-dependent protein kinase; PKB (AKT): protein kinase B; PKG: cGMP-dependent protein kinase; PPARγ: peroxisome proliferator-activated receptor-γ; SGLT1: sodium-dependent glucose transporter 1; SI: sucrase-isomaltase; T2DM: type 2 diabetes mellitus; TNFα: tumor necrosis factor-α. 30773997 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE Our results identify a novel ERK/hnRNPK/DDX3X pathway that influences β cell survival and is activated under conditions associated with T2D. 31178390 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE In addition, type 2 diabetes mellitus promoted a more aggressive phenotype associated with up-regulated p38 MAPK activity, which was effectively inhibited by VCP979. 31072439 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE These findings indicate that WSZYF may become a new drug candidate in the treatment of T2DM and its antidiabetic mechanism is probably inhibiting pancreatic <i>β</i> cell apoptosis by modulating the MEK-ERK-Caspase-3 signaling pathway. 30356368 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 AlteredExpression disease BEFREE STZ/nicotinamide-induced T2DM increased the expression of mitogen-activated protein kinases (MAPKs: p38, ERK, JNK) and inflammatory p65 protein. 29475461 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 GeneticVariation disease BEFREE In the present study, adult male C57BL/6J mice with streptozotocin (STZ)-induced T2DM mice were subjected to photothrombotic ischemic stroke and treatment with p38 MAPK inhibitors. 29663930 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE This study aimed to investigate whether p38 MAPK contributes to the pathogenesis of T2DM. 30284474 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE β-arrestin-2 is involved in irisin induced glucose metabolism in type 2 diabetes via p38 MAPK signaling. 28888936 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Results of immunofluorescence confocal microscopy showed that translocation of NF-κB decreased upon BOD and MOD treatments, with a decreased level of p-ERK and p-p38 phosphorylation. 27876502 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease RGD The Impact of Small RNA Interference Against Homer1 on Rats with Type 2 Diabetes and ERK Phosphorylation. 27259299 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Our results indicated the considerably aberrant MAPK signaling in both insulin-sensitive tissues of T2D rat, and that the p38 may play a role as a common "hub" in the gene module response to hyperglycaemia. 25758573 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Hence, our results define a crucial role for phosphorylation on Thr48 and Ser61 of Xbp1s in the maintenance of glucose homeostasis in obesity, and they suggest that p38 MAPK activation in the livers of obese mice could lead to a new therapeutic approach to the treatment of type 2 diabetes. 21892182 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease RGD Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. 21911753 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Therapeutic disease RGD Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes. 19164460 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Biomarker disease BEFREE Rosiglitazone increased p38 activation more in C than in T2D patients; PMA-induced phosphorylation of ERK1/2 was similarly reduced in both cells. 17922475 2008