MAPK1, mitogen-activated protein kinase 1, 5594

N. diseases: 1059; N. variants: 13
Disease: Gastroenteritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017160
Disease: Gastroenteritis
Gastroenteritis 		0.020 AlteredExpression disease BEFREE We specifically identified p38 and JNK1, which are the downstream molecules of receptor tyrosine kinases (RTKs) required for efficient TGEV replication, as A9 targets through plaque assays, qRT-PCR and Western blotting assays. p38 and JNK1 inhibitors and RNA interference further showed that the inhibitory activity of A9 against TGEV infection was mainly mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. 31751591 2020
CUI: C0017160
Disease: Gastroenteritis
Gastroenteritis 		0.020 AlteredExpression disease BEFREE The results showed that miR-4331 elevated mitochondrial Ca<sup>2+</sup> level, reduced MMP, targets Retinoblastoma 1 (RB1), upregulated IL1RAP, and induced activation of p38 MAPK pathway during TGEV infection. 29217619 2018